4e0r: Difference between revisions
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==Structure of the chicken MHC class I molecule BF2*0401== | ==Structure of the chicken MHC class I molecule BF2*0401== | ||
<StructureSection load='4e0r' size='340' side='right' caption='[[4e0r]], [[Resolution|resolution]] 2.26Å' scene=''> | <StructureSection load='4e0r' size='340' side='right'caption='[[4e0r]], [[Resolution|resolution]] 2.26Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4e0r]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4e0r]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E0R FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e0r OCA], [https://pdbe.org/4e0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e0r RCSB], [https://www.ebi.ac.uk/pdbsum/4e0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e0r ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/O46790_CHICK O46790_CHICK] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 21: | Line 20: | ||
==See Also== | ==See Also== | ||
*[[Beta-2 microglobulin|Beta-2 microglobulin]] | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | ||
*[[MHC 3D structures|MHC 3D structures]] | |||
*[[MHC I 3D structures|MHC I 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Gallus gallus]] | ||
[[Category: Chen | [[Category: Large Structures]] | ||
[[Category: Gao | [[Category: Chen Y]] | ||
[[Category: Gao | [[Category: Gao F]] | ||
[[Category: Kaufman | [[Category: Gao GF]] | ||
[[Category: Qi | [[Category: Kaufman J]] | ||
[[Category: Xia | [[Category: Qi J]] | ||
[[Category: Zhang | [[Category: Xia C]] | ||
[[Category: Zhang J]] | |||
Latest revision as of 16:45, 8 November 2023
Structure of the chicken MHC class I molecule BF2*0401Structure of the chicken MHC class I molecule BF2*0401
Structural highlights
FunctionPublication Abstract from PubMedThe MHC has genetic associations with many diseases, often due to differences in presentation of antigenic peptides by polymorphic MHC molecules to T lymphocytes of the immune system. In chickens, only a single classical class I molecule in each MHC haplotype is expressed well due to coevolution with the polymorphic TAPs which means that resistance and susceptibility to infectious pathogens are particularly easy to observe. Previously, structures of chicken MHC class I molecule BF2*2101 from B21 haplotype showed an unusually large peptide-binding groove that accommodates a broad spectrum of peptides to present as epitopes to CTLs, explaining the MHC-determined resistance of B21 chickens to Marek's disease. In this study, we report the crystal structure of BF2*0401 from the B4 (also known as B13) haplotype, showing a highly positively charged surface hitherto unobserved in other MHC molecules, as well as a remarkably narrow groove due to the allele-specific residues with bulky side chains. Together, these properties limit the number of epitope peptides that can bind this class I molecule. However, peptide-binding assays show that in vitro, BF2*0401 can bind a wider variety of peptides than are found on the surface of B4 cells. Thus, a combination of the specificities of the polymorphic TAP and the MHC results in a very limited set of BF2*0401 peptides with negatively charged anchors to be presented to T lymphocytes. Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens.,Zhang J, Chen Y, Qi J, Gao F, Liu Y, Liu J, Zhou X, Kaufman J, Xia C, Gao GF J Immunol. 2012 Nov 1;189(9):4478-87. doi: 10.4049/jimmunol.1200885. Epub 2012, Oct 5. PMID:23041567[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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