3lp6: Difference between revisions

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==Crystal Structure of Rv3275c-E60A from Mycobacterium tuberculosis at 1.7A resolution==
==Crystal Structure of Rv3275c-E60A from Mycobacterium tuberculosis at 1.7A resolution==
<StructureSection load='3lp6' size='340' side='right' caption='[[3lp6]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3lp6' size='340' side='right'caption='[[3lp6]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3lp6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LP6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3lp6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LP6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.702&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT3375, MTCY71.15c, purE, Rv3275c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lp6 OCA], [https://pdbe.org/3lp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lp6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lp6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lp6 OCA], [http://pdbe.org/3lp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lp6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PURE_MYCTU PURE_MYCTU] Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lp/3lp6_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lp/3lp6_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Phosphoribosylaminoimidazole carboxylase|Phosphoribosylaminoimidazole carboxylase]]
*[[Phosphoribosylaminoimidazole carboxylase 3D structures|Phosphoribosylaminoimidazole carboxylase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Phosphoribosylaminoimidazole carboxylase]]
[[Category: Large Structures]]
[[Category: Hung, L W]]
[[Category: Mycobacterium tuberculosis]]
[[Category: ISFI, Integrated Center for Structure and Function Innovation]]
[[Category: Hung L-W]]
[[Category: Kim, C Y]]
[[Category: Kim C-Y]]
[[Category: Kim, H]]
[[Category: Kim H]]
[[Category: Structural genomic]]
[[Category: Terwilliger TC]]
[[Category: Terwilliger, T C]]
[[Category: Yu M]]
[[Category: Yu, M]]
[[Category: Alpha and beta protein]]
[[Category: Decarboxylase]]
[[Category: Integrated center for structure and function innovation]]
[[Category: Isfi]]
[[Category: Lyase]]
[[Category: PSI, Protein structure initiative]]
[[Category: Purine biosynthesis]]
[[Category: Tbsgc]]

Latest revision as of 13:21, 21 February 2024

Crystal Structure of Rv3275c-E60A from Mycobacterium tuberculosis at 1.7A resolutionCrystal Structure of Rv3275c-E60A from Mycobacterium tuberculosis at 1.7A resolution

Structural highlights

3lp6 is a 4 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.702Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PURE_MYCTU Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3lp6, resolution 1.70Å

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OCA