4f4o: Difference between revisions

<StructureSection load='4f4o' size='340' side='right' caption='[[4f4o]], [[Resolution|resolution]] 2.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[4f4o]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4O FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4o OCA], [http://pdbe.org/4f4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f4o RCSB], [http://www.ebi.ac.uk/pdbsum/4f4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f4o ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/HBA_PIG HBA_PIG]] Involved in oxygen transport from the lung to the various peripheral tissues. [[http://www.uniprot.org/uniprot/HPT_PIG HPT_PIG]] As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).  Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. [[http://www.uniprot.org/uniprot/HBB_PIG HBB_PIG]] Involved in oxygen transport from the lung to the various peripheral tissues.  

[[Category: Andersen, C B.F]]

[[Category: Andersen, G R]]

[[Category: Andersen, N H]]

[[Category: Hersleth, H P]]

[[Category: Moestrup, S K]]

[[Category: Nielsen, M J]]

[[Category: Oliveira, C L.P]]

[[Category: Pedersen, J S]]

[[Category: Torvund-Jensen, M]]

[[Category: Serine protease fold]]