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[[Image:1aq2.gif|left|200px]]<br />
<applet load="1aq2" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1aq2, resolution 1.9&Aring;" />
'''PHOSPHOENOLPYRUVATE CARBOXYKINASE'''<br />


==About this Structure==
==PHOSPHOENOLPYRUVATE CARBOXYKINASE==
1AQ2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with MN, MG, ATP and PYR as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(ATP) Phosphoenolpyruvate carboxykinase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.49 4.1.1.49] Structure known Active Site: ACT. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AQ2 OCA].  
<StructureSection load='1aq2' size='340' side='right'caption='[[1aq2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1aq2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQ2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aq2 OCA], [https://pdbe.org/1aq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aq2 RCSB], [https://www.ebi.ac.uk/pdbsum/1aq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aq2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PCKA_ECOLI PCKA_ECOLI]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aq2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aq2 ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Mg(2+)-Mn2+ clusters in enzyme-catalyzed phosphoryl-transfer reactions., Tari LW, Matte A, Goldie H, Delbaere LT, Nat Struct Biol. 1997 Dec;4(12):990-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9406547 9406547]
*[[Phosphoenolpyruvate carboxykinase 3D structures|Phosphoenolpyruvate carboxykinase 3D structures]]
[[Category: Escherichia coli]]
__TOC__
[[Category: Phosphoenolpyruvate carboxykinase (ATP)]]
</StructureSection>
[[Category: Single protein]]
[[Category: Escherichia coli K-12]]
[[Category: Delbaere, L.T.J.]]
[[Category: Large Structures]]
[[Category: Goldie, H.]]
[[Category: Delbaere LTJ]]
[[Category: Matte, A.]]
[[Category: Goldie H]]
[[Category: Tari, L.W.]]
[[Category: Matte A]]
[[Category: ATP]]
[[Category: Tari LW]]
[[Category: MG]]
[[Category: MN]]
[[Category: PYR]]
[[Category: gluconeogenesis]]
[[Category: kinase]]
[[Category: lyase]]
[[Category: nucleotide-triphosphate hydrolase]]
[[Category: p-loop]]
[[Category: protein-atp complex]]
[[Category: transphosphorylating]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 15:50:23 2007''

Latest revision as of 13:54, 2 August 2023

PHOSPHOENOLPYRUVATE CARBOXYKINASEPHOSPHOENOLPYRUVATE CARBOXYKINASE

Structural highlights

1aq2 is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PCKA_ECOLI

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1aq2, resolution 1.90Å

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