4es4: Difference between revisions

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==Crystal structure of YdiV and FlhD complex==
==Crystal structure of YdiV and FlhD complex==
<StructureSection load='4es4' size='340' side='right' caption='[[4es4]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='4es4' size='340' side='right'caption='[[4es4]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4es4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ES4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ES4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4es4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ES4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ES4 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tlq|3tlq]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdgR, ydiV, b1707, JW1697 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), flhD, flbB, b1892, JW1881 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4es4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4es4 OCA], [https://pdbe.org/4es4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4es4 RCSB], [https://www.ebi.ac.uk/pdbsum/4es4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4es4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4es4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4es4 OCA], [http://pdbe.org/4es4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4es4 RCSB], [http://www.ebi.ac.uk/pdbsum/4es4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4es4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/YDIV_ECOLI YDIV_ECOLI]] Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC.<ref>PMID:22461489</ref> [[http://www.uniprot.org/uniprot/FLHD_ECOLI FLHD_ECOLI]] Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.<ref>PMID:7961507</ref> <ref>PMID:11169100</ref> <ref>PMID:15941987</ref> <ref>PMID:18765794</ref> 
[https://www.uniprot.org/uniprot/YDIV_ECOLI YDIV_ECOLI] Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC.<ref>PMID:22461489</ref>  
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Gu, L]]
[[Category: Large Structures]]
[[Category: Li, B]]
[[Category: Gu L]]
[[Category: Flagellar regulation]]
[[Category: Li B]]
[[Category: Transcription]]

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