4os0: Difference between revisions

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OCA

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 ==Three-dimensional structure of the C65A-W54F double mutant of Human lipocalin-type Prostaglandin D Synthase apo-form==
-<StructureSection load='4os0' size='340' side='right' caption='[[4os0]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+<StructureSection load='4os0' size='340' side='right'caption='[[4os0]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4os0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OS0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4os0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OS0 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4orr|4orr]], [[4ors|4ors]], [[4oru|4oru]], [[4orw|4orw]], [[4orx|4orx]], [[4ory|4ory]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4os0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4os0 OCA], [https://pdbe.org/4os0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4os0 RCSB], [https://www.ebi.ac.uk/pdbsum/4os0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4os0 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4os0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4os0 OCA], [http://pdbe.org/4os0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4os0 RCSB], [http://www.ebi.ac.uk/pdbsum/4os0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4os0 ProSAT]</span></td></tr>
 </table>
-== Function ==
-[[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 4os0" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Prostaglandin D synthase|Prostaglandin D synthase]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Prostaglandin-D synthase]]
+[[Category: Homo sapiens]]
-[[Category: Bertinelli, M]]
+[[Category: Large Structures]]
-[[Category: Bertini, E]]
+[[Category: Bertinelli M]]
-[[Category: Bovi, M]]
+[[Category: Bertini E]]
-[[Category: Capaldi, S]]
+[[Category: Bovi M]]
-[[Category: Carrizo, M E]]
+[[Category: Capaldi S]]
-[[Category: Destefanis, L]]
+[[Category: Carrizo ME]]
-[[Category: Monaco, H L]]
+[[Category: Destefanis L]]
-[[Category: Perduca, M]]
+[[Category: Monaco HL]]
-[[Category: Isomerase]]
+[[Category: Perduca M]]
-[[Category: Lipocalin-type prostaglandin-d synthase]]