3po7: Difference between revisions

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==Human monoamine oxidase B in complex with zonisamide==
==Human monoamine oxidase B in complex with zonisamide==
<StructureSection load='3po7' size='340' side='right' caption='[[3po7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3po7' size='340' side='right'caption='[[3po7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3po7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PO7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3po7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PO7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZON:1-(1,2-BENZOXAZOL-3-YL)METHANESULFONAMIDE'>ZON</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAOB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZON:1-(1,2-BENZOXAZOL-3-YL)METHANESULFONAMIDE'>ZON</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3po7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3po7 OCA], [https://pdbe.org/3po7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3po7 RCSB], [https://www.ebi.ac.uk/pdbsum/3po7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3po7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3po7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3po7 OCA], [http://pdbe.org/3po7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3po7 RCSB], [http://www.ebi.ac.uk/pdbsum/3po7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3po7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.  
[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Monoamine oxidase]]
[[Category: Large Structures]]
[[Category: Aldeco, M]]
[[Category: Aldeco M]]
[[Category: Binda, C]]
[[Category: Binda C]]
[[Category: Edmondson, D E]]
[[Category: Edmondson DE]]
[[Category: Mattevi, A]]
[[Category: Mattevi A]]
[[Category: Antiparkinson drug]]
[[Category: Fad]]
[[Category: Flavin-binding amine oxidase]]
[[Category: Mitochondrial outer membrane]]
[[Category: Neurotransmitter metabolism]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

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