4m4c: Difference between revisions
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==Crystal structure of Rhodostomin ARGDP mutant== | ==Crystal structure of Rhodostomin ARGDP mutant== | ||
<StructureSection load='4m4c' size='340' side='right' caption='[[4m4c]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4m4c' size='340' side='right'caption='[[4m4c]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4m4c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4C OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4m4c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4C FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4c OCA], [https://pdbe.org/4m4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4c RCSB], [https://www.ebi.ac.uk/pdbsum/4m4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4c ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | ||
==See Also== | |||
*[[Disintegrin|Disintegrin]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Calloselasma rhodostoma]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Chang YT]] | ||
[[Category: | [[Category: Chen CY]] | ||
[[Category: | [[Category: Chuang WJ]] | ||
[[Category: | [[Category: Jeng WY]] | ||
[[Category: | [[Category: Shiu JH]] | ||
Latest revision as of 17:41, 8 November 2023
Crystal structure of Rhodostomin ARGDP mutantCrystal structure of Rhodostomin ARGDP mutant
Structural highlights
FunctionVM2RH_CALRH Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). See Also |
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