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==Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant== | ==Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant== | ||
<StructureSection load='3vpm' size='340' side='right' caption='[[3vpm]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='3vpm' size='340' side='right'caption='[[3vpm]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3vpm]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3vpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VPM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vpm OCA], [https://pdbe.org/3vpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vpm RCSB], [https://www.ebi.ac.uk/pdbsum/3vpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vpm ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RIR2_HUMAN RIR2_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. | ||
==See Also== | ==See Also== | ||
*[[Ribonucleotide reductase|Ribonucleotide reductase]] | *[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Chen B]] | ||
[[Category: Chen | [[Category: Chen X]] | ||
[[Category: Liu | [[Category: Liu H]] | ||
[[Category: Shao | [[Category: Shao J]] | ||
[[Category: Xu | [[Category: Xu Z]] | ||
[[Category: Yang | [[Category: Yang C]] | ||
[[Category: Zhang | [[Category: Zhang L]] | ||
[[Category: Zhu | [[Category: Zhu L]] | ||
[[Category: Zhu | [[Category: Zhu W]] | ||
Latest revision as of 15:31, 8 November 2023
Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutantCrystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant
Structural highlights
FunctionRIR2_HUMAN Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. See Also |
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