4ie2: Difference between revisions
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==Crystal structure of human Arginase-2 complexed with inhibitor 1h== | ==Crystal structure of human Arginase-2 complexed with inhibitor 1h== | ||
<StructureSection load='4ie2' size='340' side='right' caption='[[4ie2]], [[Resolution|resolution]] 2.21Å' scene=''> | <StructureSection load='4ie2' size='340' side='right'caption='[[4ie2]], [[Resolution|resolution]] 2.21Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ie2]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ie2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IE2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EC:[(5R)-5-AMINO-5-CARBOXY-8-HYDROXYOCTYL](TRIHYDROXY)BORATE(1-)'>1EC</scene>, <scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2082Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EC:[(5R)-5-AMINO-5-CARBOXY-8-HYDROXYOCTYL](TRIHYDROXY)BORATE(1-)'>1EC</scene>, <scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ie2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ie2 OCA], [https://pdbe.org/4ie2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ie2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ie2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ie2 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Arginase|Arginase]] | *[[Arginase 3D structures|Arginase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Andreoli | [[Category: Andreoli M]] | ||
[[Category: Beckett | [[Category: Beckett P]] | ||
[[Category: Cousido-Siah | [[Category: Cousido-Siah A]] | ||
[[Category: Golebiowski | [[Category: Golebiowski A]] | ||
[[Category: Jagdmann | [[Category: Jagdmann E]] | ||
[[Category: Ji | [[Category: Ji MK]] | ||
[[Category: Mazur | [[Category: Mazur A]] | ||
[[Category: Mitschler | [[Category: Mitschler A]] | ||
[[Category: Padmanilayam | [[Category: Padmanilayam M]] | ||
[[Category: Podjarny | [[Category: Podjarny A]] | ||
[[Category: Ruiz | [[Category: Ruiz FX]] | ||
[[Category: Ryder | [[Category: Ryder T]] | ||
[[Category: Schroeter | [[Category: Schroeter H]] | ||
[[Category: | [[Category: Van Zandt MC]] | ||
[[Category: Whitehouse D]] | |||
[[Category: | |||