4zs7: Difference between revisions

<StructureSection load='4zs7' size='340' side='right' caption='[[4zs7]], [[Resolution|resolution]] 2.93&Aring;' scene=''>

<table><tr><td colspan='2'>[[4zs7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZS7 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zs7 OCA], [http://pdbe.org/4zs7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zs7 RCSB], [http://www.ebi.ac.uk/pdbsum/4zs7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zs7 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.  Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.  

[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.  

[[Category: Blanchetot, C]]

[[Category: Cambillau, C]]

[[Category: Desmyter, A]]

[[Category: Haard, H de]]

[[Category: Hofman, E]]

[[Category: Hultberg, A]]

[[Category: Jonge, N De]]

[[Category: Klarenbeek, A]]

[[Category: Kretz-Rommel, A]]

[[Category: Loris, R]]

[[Category: Ongenae, N]]

[[Category: Sadi, A]]

[[Category: Spinelli, S]]

[[Category: Dromedery]]

[[Category: Fab fragment]]

[[Category: Immune system]]

[[Category: Interleukine 6 complex]]