1j9j: Difference between revisions

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[[Image:1j9j.jpg|left|200px]]


{{Structure
==CRYSTAL STRUCTURE ANALYSIS OF SURE PROTEIN FROM T.MARITIMA==
|PDB= 1j9j |SIZE=350|CAPTION= <scene name='initialview01'>1j9j</scene>, resolution 1.90&Aring;
<StructureSection load='1j9j' size='340' side='right'caption='[[1j9j]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[1j9j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J9J FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j9j OCA], [https://pdbe.org/1j9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j9j RCSB], [https://www.ebi.ac.uk/pdbsum/1j9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j9j ProSAT]</span></td></tr>
|RELATEDENTRY=[[1j9k|1J9K]], [[1j9l|1J9L]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j9j OCA], [http://www.ebi.ac.uk/pdbsum/1j9j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j9j RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/SURE_THEMA SURE_THEMA] Nucleotidase that preferentially dephosphorylates 5'-GMP and 5'-AMP.[HAMAP-Rule:MF_00060]
 
== Evolutionary Conservation ==
'''CRYSTAL STRUCTURE ANALYSIS OF SURE PROTEIN FROM T.MARITIMA'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j9/1j9j_consurf.spt"</scriptWhenChecked>
Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their gene products. We have determined the crystal structure of the SurE protein from Thermotoga maritima. The structure reveals the dimeric arrangement of the subunits and an active site around a bound metal ion. We also demonstrate that the SurE protein exhibits a divalent metal ion-dependent phosphatase activity that is inhibited by vanadate or tungstate. In the vanadate- and tungstate-complexed structures, the inhibitors bind adjacent to the divalent metal ion. Our structural and functional analyses identify the SurE proteins as a novel family of metal ion-dependent phosphatases.
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1J9J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9J OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j9j ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family., Lee JY, Kwak JE, Moon J, Eom SH, Liong EC, Pedelacq JD, Berendzen J, Suh SW, Nat Struct Biol. 2001 Sep;8(9):789-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11524683 11524683]
</StructureSection>
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Kwak, J E.]]
[[Category: Kwak JE]]
[[Category: Lee, J Y.]]
[[Category: Lee JY]]
[[Category: Moon, J.]]
[[Category: Moon J]]
[[Category: Suh, S W.]]
[[Category: Suh SW]]
[[Category: sure protein]]
[[Category: thermotoga maritima]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:30:28 2008''

Latest revision as of 16:24, 13 March 2024

CRYSTAL STRUCTURE ANALYSIS OF SURE PROTEIN FROM T.MARITIMACRYSTAL STRUCTURE ANALYSIS OF SURE PROTEIN FROM T.MARITIMA

Structural highlights

1j9j is a 2 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SURE_THEMA Nucleotidase that preferentially dephosphorylates 5'-GMP and 5'-AMP.[HAMAP-Rule:MF_00060]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1j9j, resolution 1.90Å

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