3tie: Difference between revisions
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==Crystal structure of the vaccinia derived peptide A11R in complex with the murine MHC CLASS I H-2 KB== | ==Crystal structure of the vaccinia derived peptide A11R in complex with the murine MHC CLASS I H-2 KB== | ||
<StructureSection load='3tie' size='340' side='right' caption='[[3tie]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='3tie' size='340' side='right'caption='[[3tie]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3tie]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3tie]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TIE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tie OCA], [https://pdbe.org/3tie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tie RCSB], [https://www.ebi.ac.uk/pdbsum/3tie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tie ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 20: | ||
==See Also== | ==See Also== | ||
*[[Beta-2 microglobulin|Beta-2 microglobulin]] | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | ||
*[[MHC 3D structures|MHC 3D structures]] | |||
*[[MHC I 3D structures|MHC I 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: | [[Category: Vaccinia virus]] | ||
[[Category: | [[Category: Nguyen TT]] | ||
[[Category: | [[Category: Shen ZT]] | ||
[[Category: | [[Category: Stern LJ]] | ||
Latest revision as of 09:49, 27 November 2024
Crystal structure of the vaccinia derived peptide A11R in complex with the murine MHC CLASS I H-2 KBCrystal structure of the vaccinia derived peptide A11R in complex with the murine MHC CLASS I H-2 KB
Structural highlights
FunctionHA1B_MOUSE Involved in the presentation of foreign antigens to the immune system. Publication Abstract from PubMedClosely related peptide epitopes can be recognized by the same T cells and contribute to the immune response against pathogens encoding those epitopes, but sometimes cross-reactive epitopes share little homology. The degree of structural homology required for such disparate ligands to be recognized by cross-reactive TCRs remains unclear. In this study, we examined the mechanistic basis for cross-reactive T cell responses between epitopes from unrelated and pathogenic viruses, lymphocytic choriomeningitis virus (LCMV) and vaccinia virus. Our results show that the LCMV cross-reactive T cell response toward vaccinia virus is dominated by a shared asparagine residue, together with other shared structural elements conserved in the crystal structures of K(b)-VV-A11R and K(b)-LCMV-gp34. Based on analysis of the crystal structures and the specificity determinants for the cross-reactive T cell response, we were able to manipulate the degree of cross-reactivity of the T cell response, and to predict and generate a LCMV cross-reactive response toward a variant of a null OVA-derived peptide. These results indicate that protective heterologous immune responses can occur for disparate epitopes from unrelated viruses. Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.,Shen ZT, Nguyen TT, Daniels KA, Welsh RM, Stern LJ J Immunol. 2013 Nov 15;191(10):5139-52. doi: 10.4049/jimmunol.1300852. Epub 2013 , Oct 14. PMID:24127554[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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