5fyb: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fyb is ON HOLD  until Paper Publication
+==Crystal structure of the catalytic domain of human JARID1B in complex with MC1648==
+<StructureSection load='5fyb' size='340' side='right'caption='[[5fyb]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fyb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FYB FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=77J:N-HYDROXY-3-[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]PROPANAMIDE'>77J</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fyb OCA], [https://pdbe.org/5fyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fyb RCSB], [https://www.ebi.ac.uk/pdbsum/5fyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fyb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
-Authors: Nowak, R., Srikannathasan, V., Rotili, D., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
+==See Also==
+*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
-Description: Crystal structure of the catalytic domain of human JARID1B in complex with MC1648
+*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
-[[Category: Unreleased Structures]]
+== References ==
-[[Category: Nowak, R]]
+<references/>
-[[Category: Rotili, D]]
+__TOC__
-[[Category: Burgess-Brown, N.A]]
+</StructureSection>
-[[Category: Bountra, C]]
+[[Category: Homo sapiens]]
-[[Category: Kupinska, K]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Arrowsmith CH]]
-[[Category: Gileadi, C]]
+[[Category: Bountra C]]
-[[Category: Oppermann, U]]
+[[Category: Burgess-Brown NA]]
-[[Category: Szykowska, A]]
+[[Category: Edwards AM]]
-[[Category: Von Delft, F]]
+[[Category: Gileadi C]]
-[[Category: Edwards, A.M]]
+[[Category: Johansson C]]
-[[Category: Johansson, C]]
+[[Category: Kupinska K]]
-[[Category: Strain-Damerell, C]]
+[[Category: Nowak R]]
-[[Category: Srikannathasan, V]]
+[[Category: Oppermann U]]
+[[Category: Rotili D]]
+[[Category: Srikannathasan V]]
+[[Category: Strain-Damerell C]]
+[[Category: Szykowska A]]
+[[Category: Von Delft F]]