1hkf: Difference between revisions

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-[[Image:1hkf.gif|left|200px]]
- {{Structure
+==The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity==
-|PDB= 1hkf |SIZE=350|CAPTION= <scene name='initialview01'>1hkf</scene>, resolution 2.2&Aring;
+<StructureSection load='1hkf' size='340' side='right'caption='[[1hkf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1hkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKF FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkf OCA], [https://pdbe.org/1hkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkf RCSB], [https://www.ebi.ac.uk/pdbsum/1hkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkf ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkf OCA], [http://www.ebi.ac.uk/pdbsum/1hkf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hkf RCSB]</span>
+[https://www.uniprot.org/uniprot/NCTR2_HUMAN NCTR2_HUMAN] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:10049942</ref>
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hkf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hkf ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 A crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.
-'''THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY'''
+The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.,Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D Structure. 2003 Jun;11(6):725-34. PMID:12791260<ref>PMID:12791260</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1hkf" style="background-color:#fffaf0;"></div>
-==Overview==
+==See Also==
-Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 A crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.
+*[[NK cell receptor|NK cell receptor]]
+== References ==
-==About this Structure==
+<references/>
-HKF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA].
+__TOC__
+</StructureSection>
-==Reference==
-The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity., Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D, Structure. 2003 Jun;11(6):725-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12791260 12791260]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Biassoni, R.]]
+[[Category: Biassoni R]]
-[[Category: Bolognesi, M.]]
+[[Category: Bolognesi M]]
-[[Category: Bordo, D.]]
+[[Category: Bordo D]]
-[[Category: Cantoni, C.]]
+[[Category: Cantoni C]]
-[[Category: Conte, R.]]
+[[Category: Conte R]]
-[[Category: Moretta, A.]]
+[[Category: Moretta A]]
-[[Category: Moretta, L.]]
+[[Category: Moretta L]]
-[[Category: Ponassi, M.]]
+[[Category: Ponassi M]]
-[[Category: Spallarossa, A.]]
+[[Category: Spallarossa A]]
-[[Category: immunoglobulin domain]]
-[[Category: natural cytotoxicity receptor]]
-[[Category: nkp44,receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:06:45 2008''