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==The Substrate Binding Mode and Chemical Basis of a Reaction Specificity Switch in Oxalate Decarboxylase==
==The Substrate Binding Mode and Chemical Basis of a Reaction Specificity Switch in Oxalate Decarboxylase==
<StructureSection load='5hi0' size='340' side='right' caption='[[5hi0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5hi0' size='340' side='right'caption='[[5hi0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5hi0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HI0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5hi0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HI0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.602&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxalate_decarboxylase Oxalate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.2 4.1.1.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hi0 OCA], [http://pdbe.org/5hi0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hi0 RCSB], [http://www.ebi.ac.uk/pdbsum/5hi0 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hi0 OCA], [https://pdbe.org/5hi0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hi0 RCSB], [https://www.ebi.ac.uk/pdbsum/5hi0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hi0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OXDC_BACSU OXDC_BACSU]] Converts oxalate to formate and CO(2) in an O(2)-dependent reaction. Can also catalyze minor side reactions: oxalate oxidation to produce H(2)O(2), and oxalate-dependent, H(2)O(2)-independent dye oxidations.  
[https://www.uniprot.org/uniprot/OXDC_BACSU OXDC_BACSU] Converts oxalate to formate and CO(2) in an O(2)-dependent reaction. Can also catalyze minor side reactions: oxalate oxidation to produce H(2)O(2), and oxalate-dependent, H(2)O(2)-independent dye oxidations.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Oxalate decarboxylase]]
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Allen, K N]]
[[Category: Large Structures]]
[[Category: Cohen, S E]]
[[Category: Allen KN]]
[[Category: Easthon, L M]]
[[Category: Cohen SE]]
[[Category: Reinhardt, L A]]
[[Category: Easthon LM]]
[[Category: Richards, N G.J]]
[[Category: Reinhardt LA]]
[[Category: Silverman, D N]]
[[Category: Richards NGJ]]
[[Category: Tu, C]]
[[Category: Silverman DN]]
[[Category: Zhu, W]]
[[Category: Tu C]]
[[Category: Lyase]]
[[Category: Zhu W]]
[[Category: Oxireductase]]

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