NAD(P) transhydrogenase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='1u2d' size='350' side='right' caption='Structure of PTH domains I (grey and green) and III (pink) complex with NAD and NADP (PDB entry [[1u2d]])' scene=''>
+<StructureSection load='' size='450' side='right' caption='Structure of PTH domains I (cyan and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry [[1u2d]])' scene='57/571286/Cv/1'>
 '''NAD(P) transhydrogenase'''  (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD.  See [[NAD]] and [[NAD(P)H]].  The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>.  PTH uses FAD as cofactor.
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 * Domain II is a membrane-spanning domain.<br />
 * Domain III binds NADP(+)/NADPH.<br />
-PTH is composed of 2 subunits.  Subunit β contains domain III and part of II.  The active site of PTH contains NAD in domain I and NADP in domain III<ref>PMID:15323555</ref>.
+PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains <scene name='57/571286/Cv/6'>NAD in domain I</scene> and <scene name='57/571286/Cv/7'>NADP in domain III</scene><ref>PMID:15323555</ref>. Water molecules are shown as red spheres.
-</StructureSection>
 ==3D structures of NAD(P) transhydrogenase==
+[[NAD(P) transhydrogenase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*NAD(P) transhydrogenase domain I
-**[[1l7d]] – RrPTH domain I – ''Rhodospirillum rubrum'' <br />
-**[[1l7e]] – RrPTH domain I + NAD <br />
-**[[1x13]] – EcPTH domain I – ''Escherichia coli'' <br />
-**[[1x14]], [[1x15]] – EcPTH domain I + NAD <br />
-**[[4dio]] – PTH domain I – ''Sinorhizobium meliloti''<br />
-*PTH domain II
-**[[4o93]], [[4o9p]], [[4o9t]], [[4o9u]] – TtPTH domain II – ''Thermus thermophilus''<br />
-*NAD(P) transhydrogenase domain III
-**[[1e3t]] – RrPTH domain III + NADP - NMR<br />
-**[[1pno]] – RrPTH domain III + NADP <br />
-**[[1pnq]] – RrPTH domain III + NADPH <br />
-**[[1d4o]] – bPTH domain III + NADP - bovine<br />
-**[[1djl]], [[1u31]] – hPTH domain III + NADP - human<br />
-**[[1pt9]] – hPTH domain III + NADP analog<br />
-*NAD(P) transhydrogenase domain I+III
-**[[1hzz]], [[1u28]], [[1u2d]], [[1xlt]] – RrPTH domain I+III + NADP + NAD<br />
-**[[1f8g]] – RrPTH domain I+III + NAD<br />
-**[[1nm5]], [[2fr8]], [[2fsv]] – RrPTH domain I+III (mutant) + NADP + NAD<br />
-**[[1ptj]], [[1u2g]], [[2frd]], [[2oo5]] – RrPTH domain I+III + NADP + NAD derivative<br />
-**[[2oor]] – RrPTH domain I+III + NADP derivative + NAD<br />
-**[[2bru]] – EcPTH domain I+III + NADP + NAD - NMR<br />
-**[[4j16]], [[4j1t]] – TtPTH domain I+III + NADP + NAD <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]