Isopropylmalate isomerase: Difference between revisions
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<StructureSection load=' | <StructureSection load='1v7l' size='340' side='right' caption='3-isopropylmalate isomerase small subunit (PDB code [[1v7l]])' scene=''> | ||
== Function == | == Function == | ||
'''Isopropylmalate isomerase''' (IPMI) catalyzes a stereo-specific isomerization of 3-isopropylmalate by dehydration followed by rehydration at a different position to 2-isopropylmalate | '''Isopropylmalate isomerase''' (IPMI) catalyzes a stereo-specific isomerization of 3-isopropylmalate by dehydration followed by rehydration at a different position to 2-isopropylmalate. IPMI is a homodimer composed of a large subunit (LeuC) and a small subunit (LeuD)<ref>PMID:15522288</ref>. | ||
</StructureSection> | </StructureSection> | ||
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[[2hcu]] – SmIPMI small subunit – ''Streptococcus mutans''<br / > | [[2hcu]] – SmIPMI small subunit – ''Streptococcus mutans''<br / > | ||
[[3q3w]] – CjIPMI small subunit – ''Campylobacter jejuni''<br / > | [[3q3w]] – CjIPMI small subunit – ''Campylobacter jejuni''<br / > | ||
[[3vba]] – MjIPMI small subunit – ''Methanocaldococcus janaschii''<br / > | [[3vba]], [[2pkp]] – MjIPMI small subunit – ''Methanocaldococcus janaschii''<br / > | ||
[[4kp1]], [[4nqy]] – MjIPMI large subunit <br / > | [[4kp1]], [[4nqy]] – MjIPMI large subunit <br / > | ||
[[3h5e]], [[ | [[3h5e]], [[3h5h]], [[3h5j]] – MtIPMI small subunit – ''Mycobacterium tuberculosis''<br / > | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
Latest revision as of 01:26, 20 October 2017
FunctionIsopropylmalate isomerase (IPMI) catalyzes a stereo-specific isomerization of 3-isopropylmalate by dehydration followed by rehydration at a different position to 2-isopropylmalate. IPMI is a homodimer composed of a large subunit (LeuC) and a small subunit (LeuD)[1].
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3D structures of Isopropylmalate isomerase3D structures of Isopropylmalate isomerase
Updated on 20-October-2017
1v7l – PhIPMI small subunit – Pyrococcus horikoshii
2hcu – SmIPMI small subunit – Streptococcus mutans
3q3w – CjIPMI small subunit – Campylobacter jejuni
3vba, 2pkp – MjIPMI small subunit – Methanocaldococcus janaschii
4kp1, 4nqy – MjIPMI large subunit
3h5e, 3h5h, 3h5j – MtIPMI small subunit – Mycobacterium tuberculosis
ReferencesReferences
- ↑ Yasutake Y, Yao M, Sakai N, Kirita T, Tanaka I. Crystal structure of the Pyrococcus horikoshii isopropylmalate isomerase small subunit provides insight into the dual substrate specificity of the enzyme. J Mol Biol. 2004 Nov 19;344(2):325-33. PMID:15522288 doi:10.1016/j.jmb.2004.09.035