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Insulin-like growth factor binding protein: Difference between revisions

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<StructureSection load='2dsp' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='2dsp' size='340' side='right' caption='Insulin-like growth factor binding protein N terminal (green) complex with Insulin-like growth factor I (wheat) (PDB code [[2dsp]])' scene=''>
== Function ==
== Function ==
Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I (IGF I)<ref>PMID:10605625</ref>.  The N-terminal of IGFBP is the domain which binds IGF I.
Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I (IGF I)<ref>PMID:10605625</ref>.  The N-terminal of IGFBP is the domain which binds IGF I.


== Disease ==
== Disease ==
*IGFBP-3 and IGFBP-6 show inhibition of angiogenesis and promotion of cancer cell migration<ref>PMID:23126425</ref>,<ref>PMID:9815544</ref.  <br />
*IGFBP-3 and IGFBP-6 show inhibition of angiogenesis and promotion of cancer cell migration<ref>PMID:23126425</ref>,<ref>PMID:9815544</ref>.  <br />
*IGFBP-3 level is decreased in patients with inflammatory bowel disease<ref>PMID:15844718</ref>.<br />
*IGFBP-3 level is decreased in patients with inflammatory bowel disease<ref>PMID:15844718</ref>.<br />
*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br />
*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br />
*IGFBP-1 is closely related to risk factors for diabetes and cardiovascular disease<ref>PMID:11317665</ref>.  
*IGFBP-1 is closely related to risk factors for diabetes and cardiovascular disease<ref>PMID:11317665</ref>.  


== Relevance ==
==3D structures of insulin-like growth factor binding protein==
 
[[Insulin-like growth factor binding protein 3D structures]]
== Structural highlights ==


</StructureSection>
</StructureSection>
==3D structures of insulin-like growth factor binding protein==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*IGF binding protein 1
**[[1zt3]], [[1zt5]] – hIGFBP C terminal + IGF I – human <br />
**[[2dsq]] – hIGFBP C terminal + hIGFBP-4 N terminal + IGF I  <br />
*IGF binding protein 2
**[[2h7t]] – hIGFBP C terminal – NMR<br />
*IGF binding protein 4
**[[1wqj]], [[2dsp]] – hIGFBP binding domain + IGF I  <br />
**[[2dsr]] – hIGFBP N terminal + C terminal  + IGF I  <br />
*IGF binding protein 5
**[[1boe]] – hIGFBP binding domain + IGF I – NMR<br />
**[[1h59]] – hIGFBP binding domain + IGF I <br />
*IGF binding protein 6


**[[1rmj]] – hIGFBP C terminal – NMR<br />
**[[2jm2]] – hIGFBP N terminal – NMR<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

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Michal Harel
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