5ijd: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ijd is ON HOLD
+==The crystal structure of mouse TLR4/MD-2/lipid A complex==
+<StructureSection load='5ijd' size='340' side='right'caption='[[5ijd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ijd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hg6 5hg6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IJD FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=LP4:2-DEOXY-3-O-[(3R)-3-HYDROXYTETRADECANOYL]-2-{[(3R)-3-HYDROXYTETRADECANOYL]AMINO}-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>LP4</scene>, <scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ijd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijd OCA], [https://pdbe.org/5ijd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ijd RCSB], [https://www.ebi.ac.uk/pdbsum/5ijd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ijd ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE] Note=The protein is encoded by the Lps locus, an important susceptibility locus, influencing the propensity to develop a disseminated Gram-negative infection.
+== Function ==
+[https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU] [https://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:10952994</ref>
-Authors: Wang, Y., Su, L., Morin, M.D., Jones, B.T., Whitby, L.R., Surakattula, M., Huang, H., Shi, H., Choi, J.H., Wang, K., Moresco, E.M., Berger, M., Zhan, X., Zhang, H., Boger, D.L., Beutler, B.
+==See Also==
+*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
-Description: The crystal structure of mouse TLR4/MD-2/lipid A complex
+*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
-[[Category: Unreleased Structures]]
+== References ==
-[[Category: Zhang, H]]
+<references/>
-[[Category: Wang, Y]]
+__TOC__
-[[Category: Jones, B.T]]
+</StructureSection>
-[[Category: Choi, J.H]]
+[[Category: Eptatretus burgeri]]
-[[Category: Whitby, L.R]]
+[[Category: Large Structures]]
-[[Category: Beutler, B]]
+[[Category: Mus musculus]]
-[[Category: Wang, K]]
+[[Category: Berger M]]
-[[Category: Berger, M]]
+[[Category: Beutler B]]
-[[Category: Zhan, X]]
+[[Category: Boger DL]]
-[[Category: Huang, H]]
+[[Category: Choi JH]]
-[[Category: Su, L]]
+[[Category: Huang H]]
-[[Category: Surakattula, M]]
+[[Category: Jones BT]]
-[[Category: Boger, D.L]]
+[[Category: Moresco EM]]
-[[Category: Morin, M.D]]
+[[Category: Morin MD]]
-[[Category: Moresco, E.M]]
+[[Category: Shi H]]
-[[Category: Shi, H]]
+[[Category: Su L]]
+[[Category: Surakattula M]]
+[[Category: Wang K]]
+[[Category: Wang Y]]
+[[Category: Whitby LR]]
+[[Category: Zhan X]]
+[[Category: Zhang H]]