4ybl: Difference between revisions

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 ==Crystal structure of the stabilized inner domain of clade A/E HIV-1 gp120 in complex with the ADCC mediating ANTI-HIV-1 antibody A32==
-<StructureSection load='4ybl' size='340' side='right' caption='[[4ybl]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+<StructureSection load='4ybl' size='340' side='right'caption='[[4ybl]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ybl]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YBL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ybl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YBL FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tnm|3tnm]], [[4rqh|4rqh]], [[4h8w|4h8w]], [[4yc2|4yc2]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ybl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ybl OCA], [http://pdbe.org/4ybl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ybl RCSB], [http://www.ebi.ac.uk/pdbsum/4ybl PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ybl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ybl OCA], [https://pdbe.org/4ybl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ybl RCSB], [https://www.ebi.ac.uk/pdbsum/4ybl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ybl ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0M3KKW9_9HIV1 A0A0M3KKW9_9HIV1]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Evidence supports a role of antibody-dependent cellular cytotoxicity (ADCC) toward transitional epitopes in the first and second constant (C1-C2) regions of gp120 (A32-like epitopes) in preventing HIV-1 infection and in vaccine-induced protection. Here, we describe the first successful attempt at isolating the inner domain (ID) of gp120 as an independent molecule that encapsulates the A32-like region within a minimal structural unit of the HIV-1 Env. Through structure-based design, we developed ID2, which consists of the ID expressed independently of the outer domain and stabilized in the CD4-bound conformation by an inter-layer disulfide bond. ID2 expresses C1-C2 epitopes in the context of CD4-triggered full-length gp120 but without any known neutralizing epitope present. Thus, ID2 represents a novel probe for the analysis and/or selective induction of antibody responses to the A32 epitope region. We also present the crystal structure of ID2 complexed with mAb A32, which defines its epitope.
+Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.,Tolbert WD, Gohain N, Veillette M, Chapleau JP, Orlandi C, Visciano ML, Ebadi M, DeVico AL, Fouts TR, Finzi A, Lewis GK, Pazgier M Structure. 2016 May 3;24(5):697-709. doi: 10.1016/j.str.2016.03.005. Epub 2016, Mar 31. PMID:27041594<ref>PMID:27041594</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4ybl" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Antibody 3D structures|Antibody 3D structures]]
+*[[Gp120 3D structures|Gp120 3D structures]]
+*[[3D structures of human antibody|3D structures of human antibody]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Gohain, N]]
+[[Category: Homo sapiens]]
-[[Category: Pazgier, M]]
+[[Category: Human immunodeficiency virus 1]]
-[[Category: Tolbert, W D]]
+[[Category: Large Structures]]
-[[Category: Adcc]]
+[[Category: Gohain N]]
-[[Category: Anti-hiv-1 env antibody a32]]
+[[Category: Pazgier M]]
-[[Category: Cd4i antibody]]
+[[Category: Tolbert WD]]
-[[Category: Hiv-1 env]]
-[[Category: Non-neutralizing]]
-[[Category: Viral glycoprotein gp120]]
-[[Category: Viral protein-immune system complex]]