Ficolin: Difference between revisions
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'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>. 3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''. | '''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>. 3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''. | ||
*'''Fiicolin-1''' or '''M-ficolin''' is a pattern recognition molecule of the complement system expressed in myeloid cells<ref>PMID:18343499</ref>. | |||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
<scene name='46/466464/Cv/ | <scene name='46/466464/Cv/4'>Human H-ficolin binding domain trimer</scene>. | ||
<scene name='46/466464/Cv/ | <scene name='46/466464/Cv/5'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref> Water molecules shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Ficolin == | == 3D Structures of Ficolin == | ||