Poly(A) RNA polymerase: Difference between revisions

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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-<StructureSection load='4e80' size='340' side='right' caption='Cid1 complex with UTP (stick model) (PDB code [[4e80]])' scene=''>
+<StructureSection load='' size='350' side='right' caption='Cid1 complex with UTP (PDB code [[4e80]])' scene='70/706259/Cv/1'>
 == Function ==
-'''Poly(A) RNA polymerase protein Cid1''' (Caffeine-Induced Death protein 1) is involved in cell cycle arrest where it inhibits unscheduled mitosis.  Cid1 is found in fission yeast.  Cid1 exists in 3 forms: apo I consists of 4 subunits; apo II consists of 2 subunits; UTP-bound form consists of 4 subunits.  The UTP-bound form has in its N-terminal domain a catalytic triad of Asp residues which binds the UTP.
+'''Poly(A) RNA polymerase protein Cid1''' (Caffeine-Induced Death protein 1) is involved in cell cycle arrest where it inhibits unscheduled mitosis<ref>PMID:17072891</ref>.  Cid1 is found in fission yeast.  Cid1 exists in 3 forms: '''apo I''' consists of 4 subunits; '''apo II''' consists of 2 subunits; '''UTP-bound''' form consists of 4 subunits. <br />
+'''Poly(A) RNA polymerase Gld2''' is responsible for poly(A) tail lengthening.  Gld2 activity in the brain is required for long-term memory<ref>PMID:15987818</ref>.
-== Disease ==
-== Relevance ==
 == Structural highlights ==
+The UTP binding site of Cid1 is between the N-terminal and C-terminal.  The <scene name='70/706259/Cv/5'>active site</scene> contains the <scene name='70/706259/Cv/6'>catalytic triad of aspartic acids</scene> (in magenta) in the N-terminal and the <scene name='70/706259/Cv/7'>His residue</scene> (in cyan) whose two conformations select between binding of UTP and ATP to Cid1 <ref>PMID:22751018</ref>. Water molecules are shown as red spheres.
 </StructureSection>
-== 3D Structures of poly(A) RNA polymerase protein Cid1 ==
+== 3D Structures of poly(A) RNA polymerase ==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*Poly(A) RNA polymerase Cid1
+**[[4e7x]], [[4e8f]] – fyCid1 - fission yeast<br />
+**[[4ud4]], [[4ud5]] – fyCid1 (mutant) <br />
+**[[4e80]] – fyCid1 + UTP<br />
+**[[4fh3]] – fyCid1 residues 33-377 <br />
+**[[4ep7]], [[4fh5]], [[4fhp]] – fyCid1 residues 30-377 + UTP<br />
+**[[4fhv]] – fyCid1 residues 30-377 + CTP<br />
+**[[4fhw]] – fyCid1 residues 30-377 + GTP<br />
+**[[4fhy]] – fyCid1 residues 30-377 + ATP<br />
+**[[4fhx]] – fyCid1 residues 30-377 (mutant) + ATP<br />
+**[[4nkt]] – fyCid1 residues 30-377 + UMPNPP<br />
+**[[4nku]] – fyCid1 residues 40-377 (mutant) + dinucleotide<br />
+*Poly(A) RNA polymerase Gld2 or terminal nucleotidyltransferase 2
+**[[6lbj]] - Gld2 residues 143-484 (mutant) – mouse<br />
+**[[6lbk]] - Gld2 residues 131-484 (mutant) – rat<br />
+**[[5jnb]] - CeGld2 residues 546-923 + RNP-8 – ''Caenorhabditis elegans''<br />
+**[[4zrl]] – CeGld2 residues 527-923 + defective in germ line development protein<br />
+*Poly(A) RNA polymerase
+**[[3pq1]] – hPAP (mutant) - human<br />
+}}
-[[4e7x]], [[4e8f]] – Cid1 <br />
-[[4ud4]], [[4ud5]] – Cid1 (mutant) <br />
-[[4e80]] – Cid1 + UTP<br />
-[[4fh3]] – Cid1 residues 33-377 <br />
-[[4ep7]], [[4fh5]], [[4fhp]] – Cid1 residues 30-377 + UTP<br />
-[[4fhv]] – Cid1 residues 30-377 + CTP<br />
-[[4fhw]] – Cid1 residues 30-377 + GTP<br />
-[[4fhy]] – Cid1 residues 30-377 + ATP<br />
-[[4fhx]] – Cid1 residues 30-377 (mutant) + ATP<br />
-[[4nkt]] – Cid1 residues 30-377 + UMPNPP<br />
-[[4nku]] – Cid1 residues 40-377 (mutant) + dinucleotide<br />
 == References ==
 <references/>
+[[Category:Topic Page]]