5hyo: Difference between revisions
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New page: '''Unreleased structure''' The entry 5hyo is ON HOLD Authors: St. John, S.E., Mesecar, A.D. Description: X-Ray Structure of Unbound Porcine Epidemic Diarrhea Virus 3CLpro [[Category: U... |
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==X-Ray Structure of Unbound Porcine Epidemic Diarrhea Virus 3CLpro== | |||
<StructureSection load='5hyo' size='340' side='right'caption='[[5hyo]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hyo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_epidemic_diarrhea_virus Porcine epidemic diarrhea virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.104Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyo OCA], [https://pdbe.org/5hyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hyo RCSB], [https://www.ebi.ac.uk/pdbsum/5hyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyo ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/U6BPB2_9ALPC U6BPB2_9ALPC] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.[ARBA:ARBA00002928] Nsp9 is a ssRNA-binding protein.[ARBA:ARBA00003140] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.[ARBA:ARBA00025562] | |||
==See Also== | |||
*[[Virus protease 3D structures|Virus protease 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Mesecar | [[Category: Porcine epidemic diarrhea virus]] | ||
[[Category: Mesecar AD]] | |||
[[Category: St John SE]] | |||
Latest revision as of 15:33, 6 March 2024
X-Ray Structure of Unbound Porcine Epidemic Diarrhea Virus 3CLproX-Ray Structure of Unbound Porcine Epidemic Diarrhea Virus 3CLpro
Structural highlights
FunctionU6BPB2_9ALPC Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.[ARBA:ARBA00002928] Nsp9 is a ssRNA-binding protein.[ARBA:ARBA00003140] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.[ARBA:ARBA00025562] See Also |
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