1kcm: Difference between revisions
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==Crystal Structure of Mouse PITP Alpha Void of Bound Phospholipid at 2.0 Angstroms Resolution== | ==Crystal Structure of Mouse PITP Alpha Void of Bound Phospholipid at 2.0 Angstroms Resolution== | ||
<StructureSection load='1kcm' size='340' side='right' caption='[[1kcm]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1kcm' size='340' side='right'caption='[[1kcm]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kcm]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1kcm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KCM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kcm OCA], [https://pdbe.org/1kcm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kcm RCSB], [https://www.ebi.ac.uk/pdbsum/1kcm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kcm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/PIPNA_MOUSE PIPNA_MOUSE] Note=Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PIPNA_MOUSE PIPNA_MOUSE] Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/1kcm_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/1kcm_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 33: | Line 34: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Agianian | [[Category: Mus musculus]] | ||
[[Category: Gros | [[Category: Agianian B]] | ||
[[Category: Kroon | [[Category: Gros P]] | ||
[[Category: Schouten | [[Category: Kroon J]] | ||
[[Category: Westerman | [[Category: Schouten A]] | ||
[[Category: Wirtz | [[Category: Westerman J]] | ||
[[Category: Wirtz KWA]] | |||