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==Crystal structure of the K142A mutant of E. coli MutY (core fragment)== | ==Crystal structure of the K142A mutant of E. coli MutY (core fragment)== | ||
<StructureSection load='1kg4' size='340' side='right' caption='[[1kg4]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='1kg4' size='340' side='right'caption='[[1kg4]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kg4]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1kg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KG4 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kg4 OCA], [https://pdbe.org/1kg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kg4 RCSB], [https://www.ebi.ac.uk/pdbsum/1kg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kg4 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/MUTY_ECOLI MUTY_ECOLI] Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kg4_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kg4_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 22: | Line 22: | ||
==See Also== | ==See Also== | ||
*[[DNA glycosylase|DNA glycosylase]] | *[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: Gerchman | [[Category: Large Structures]] | ||
[[Category: Gilboa | [[Category: Gerchman SE]] | ||
[[Category: Grollman | [[Category: Gilboa R]] | ||
[[Category: Kilshtein | [[Category: Grollman AP]] | ||
[[Category: Kycia | [[Category: Kilshtein A]] | ||
[[Category: Shoham | [[Category: Kycia JH]] | ||
[[Category: Zharkov | [[Category: Shoham G]] | ||
[[Category: Zharkov DO]] | |||
Latest revision as of 11:58, 16 August 2023
Crystal structure of the K142A mutant of E. coli MutY (core fragment)Crystal structure of the K142A mutant of E. coli MutY (core fragment)
Structural highlights
FunctionMUTY_ECOLI Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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