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[[Image:1fka.gif|left|200px]]


{{Structure
==STRUCTURE OF FUNCTIONALLY ACTIVATED SMALL RIBOSOMAL SUBUNIT AT 3.3 A RESOLUTION==
|PDB= 1fka |SIZE=350|CAPTION= <scene name='initialview01'>1fka</scene>, resolution 3.30&Aring;
<StructureSection load='1fka' size='340' side='right'caption='[[1fka]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>, <scene name='pdbligand=WO2:OCTADECATUNGSTENYL+DIPHOSPHATE'>WO2</scene>
<table><tr><td colspan='2'>[[1fka]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. The October 2000 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ribosome''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2000_10 10.2210/rcsb_pdb/mom_2000_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FKA FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WO2:OCTADECATUNGSTENYL+DIPHOSPHATE'>WO2</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fka OCA], [https://pdbe.org/1fka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fka RCSB], [https://www.ebi.ac.uk/pdbsum/1fka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fka ProSAT]</span></td></tr>
|RELATEDENTRY=[[1c05|1C05]], [[1pkp|1PKP]], [[1ris|1RIS]], [[1rss|1RSS]], [[1an7|1AN7]], [[1a32|1A32]], [[1ekc|1EKC]], [[1qkf|1QKF]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fka OCA], [http://www.ebi.ac.uk/pdbsum/1fka PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fka RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/RS4_THET8 RS4_THET8] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the body and platform of the 30S subunit. Binds mRNA in the 70S ribosome, positioning it for translation.[HAMAP-Rule:MF_01306_B]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/1fka_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fka ConSurf].
<div style="clear:both"></div>


'''STRUCTURE OF FUNCTIONALLY ACTIVATED SMALL RIBOSOMAL SUBUNIT AT 3.3 A RESOLUTION'''
==See Also==
 
*[[Ribosome|Ribosome]]
 
*[[Ribosome 3D structures|Ribosome 3D structures]]
==Overview==
__TOC__
The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like contact closes and contributes to processivity and fidelity. Extended RNA helical elements that run longitudinally through the body transmit structural changes, correlating events at the particle's far end with the cycle of mRNA translocation at the decoding region. 96% of the nucleotides were traced and the main fold of all proteins was determined. The latter are either peripheral or appear to serve as linkers. Some may assist the directionality of translocation.
</StructureSection>
 
[[Category: Large Structures]]
==About this Structure==
[[Category: RCSB PDB Molecule of the Month]]
1FKA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. The following page contains interesting information on the relation of 1FKA with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb10_1.html Ribosome]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKA OCA].
 
==Reference==
Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution., Schluenzen F, Tocilj A, Zarivach R, Harms J, Gluehmann M, Janell D, Bashan A, Bartels H, Agmon I, Franceschi F, Yonath A, Cell. 2000 Sep 1;102(5):615-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11007480 11007480]
[[Category: Protein complex]]
[[Category: Ribosome]]
[[Category: Ribosome]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Agmon, I.]]
[[Category: Agmon I]]
[[Category: Bartels, H.]]
[[Category: Bartels H]]
[[Category: Bashan, A.]]
[[Category: Bashan A]]
[[Category: Franceschi, F.]]
[[Category: Franceschi F]]
[[Category: Gluehmann, M.]]
[[Category: Gluehmann M]]
[[Category: Harms, J.]]
[[Category: Harms J]]
[[Category: Janell, D.]]
[[Category: Janell D]]
[[Category: Schluenzen, F.]]
[[Category: Schluenzen F]]
[[Category: Tocilj, A.]]
[[Category: Tocilj A]]
[[Category: Yonath, A.]]
[[Category: Yonath A]]
[[Category: Zarivach, R.]]
[[Category: Zarivach R]]
[[Category: 30s ribosomal subunit]]
[[Category: protein-rna complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:24:34 2008''

Latest revision as of 10:15, 7 February 2024

STRUCTURE OF FUNCTIONALLY ACTIVATED SMALL RIBOSOMAL SUBUNIT AT 3.3 A RESOLUTIONSTRUCTURE OF FUNCTIONALLY ACTIVATED SMALL RIBOSOMAL SUBUNIT AT 3.3 A RESOLUTION

Structural highlights

1fka is a 10 chain structure with sequence from Thermus thermophilus. The October 2000 RCSB PDB Molecule of the Month feature on Ribosome by David S. Goodsell is 10.2210/rcsb_pdb/mom_2000_10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RS4_THET8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the body and platform of the 30S subunit. Binds mRNA in the 70S ribosome, positioning it for translation.[HAMAP-Rule:MF_01306_B]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1fka, resolution 3.30Å

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