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==THE STRUCTURE OF E.COLI UMP KINASE IN COMPLEX WITH UDP==
 
<StructureSection load='2bnd' size='340' side='right' caption='[[2bnd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
==The structure of E. coli UMP kinase in complex with UDP==
<StructureSection load='2bnd' size='340' side='right'caption='[[2bnd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bnd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BND FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bnd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BND FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bne|2bne]], [[2bnf|2bnf]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-phosphate_kinase Nucleoside-phosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.4 2.7.4.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bnd OCA], [https://pdbe.org/2bnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bnd RCSB], [https://www.ebi.ac.uk/pdbsum/2bnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bnd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bnd OCA], [http://pdbe.org/2bnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bnd RCSB], [http://www.ebi.ac.uk/pdbsum/2bnd PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYRH_ECOLI PYRH_ECOLI] Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor.<ref>PMID:7711027</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/2bnd_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/2bnd_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Nucleoside-phosphate kinase]]
[[Category: Large Structures]]
[[Category: Assairi, L]]
[[Category: Assairi L]]
[[Category: Barzu, O]]
[[Category: Barzu O]]
[[Category: Briozzo, P]]
[[Category: Briozzo P]]
[[Category: Evrin, C]]
[[Category: Evrin C]]
[[Category: Gilles, A M]]
[[Category: Gilles AM]]
[[Category: Joly, N]]
[[Category: Joly N]]
[[Category: Meyer, P]]
[[Category: Meyer P]]
[[Category: Nucleoside monophosphate kinase]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Transferase]]

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