1f97: Difference between revisions

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[[Image:1f97.gif|left|200px]]


{{Structure
==SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE==
|PDB= 1f97 |SIZE=350|CAPTION= <scene name='initialview01'>1f97</scene>, resolution 2.5&Aring;
<StructureSection load='1f97' size='340' side='right'caption='[[1f97]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
<table><tr><td colspan='2'>[[1f97]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F97 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f97 OCA], [https://pdbe.org/1f97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f97 RCSB], [https://www.ebi.ac.uk/pdbsum/1f97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f97 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f97 OCA], [http://www.ebi.ac.uk/pdbsum/1f97 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f97 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/JAM1_MOUSE JAM1_MOUSE] Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity).
 
== Evolutionary Conservation ==
'''SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/1f97_consurf.spt"</scriptWhenChecked>
Junctional adhesion molecules (JAMs) are a family of immunoglobulin-like single-span transmembrane molecules that are expressed in endothelial cells, epithelial cells, leukocytes and myocardia. JAM has been suggested to contribute to the adhesive function of tight junctions and to regulate leukocyte trans migration. We describe the crystal structure of the recombinant extracellular part of mouse JAM (rsJAM) at 2.5 A resolution. rsJAM consists of two immunoglobulin-like domains that are connected by a conformationally restrained short linker. Two rsJAM molecules form a U-shaped dimer with highly complementary interactions between the N-terminal domains. Two salt bridges are formed in a complementary manner by a novel dimerization motif, R(V,I,L)E, which is essential for the formation of rsJAM dimers in solution and common to the known members of the JAM family. Based on the crystal packing and studies with mutant rsJAM, we propose a model for homophilic adhesion of JAM. In this model, U-shaped JAM dimers are oriented in cis on the cell surface and form a two-dimensional network by trans-interactions of their N-terminal domains with JAM dimers from an opposite cell surface.
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1F97 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F97 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f97 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif., Kostrewa D, Brockhaus M, D'Arcy A, Dale GE, Nelboeck P, Schmid G, Mueller F, Bazzoni G, Dejana E, Bartfai T, Winkler FK, Hennig M, EMBO J. 2001 Aug 15;20(16):4391-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11500366 11500366]
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Bazzoni G]]
[[Category: Arcy, A D.]]
[[Category: Brockhaus M]]
[[Category: Bazzoni, G.]]
[[Category: D'Arcy A]]
[[Category: Brockhaus, M.]]
[[Category: Dale G]]
[[Category: Dale, G.]]
[[Category: Dejana E]]
[[Category: Dejana, E.]]
[[Category: Hennig M]]
[[Category: Hennig, M.]]
[[Category: Kostrewa D]]
[[Category: Kostrewa, D.]]
[[Category: Winkler F]]
[[Category: Winkler, F.]]
[[Category: beta-sandwich fold]]
[[Category: immunoglobulin superfamily]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:18:20 2008''

Latest revision as of 13:12, 20 March 2024

SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSESOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE

Structural highlights

1f97 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

JAM1_MOUSE Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1f97, resolution 2.50Å

Drag the structure with the mouse to rotate

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OCA
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