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==Crystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative Regulator==
==Crystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative Regulator==
<StructureSection load='1tu1' size='340' side='right' caption='[[1tu1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='1tu1' size='340' side='right'caption='[[1tu1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1tu1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TU1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1tu1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TU1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA0094 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tu1 OCA], [http://pdbe.org/1tu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tu1 RCSB], [http://www.ebi.ac.uk/pdbsum/1tu1 PDBsum], [http://www.topsan.org/Proteins/MCSG/1tu1 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tu1 OCA], [https://pdbe.org/1tu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tu1 RCSB], [https://www.ebi.ac.uk/pdbsum/1tu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tu1 ProSAT], [https://www.topsan.org/Proteins/MCSG/1tu1 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EAGT6_PSEAE EAGT6_PSEAE] Plays an essential role in toxin Tse6 delivery to target cells and specifically in the loading of Tse6 onto VgrG1a.<ref>PMID:30177742</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tu1_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tu1_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 17: Line 20:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tu1 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tu1 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pseae]]
[[Category: Large Structures]]
[[Category: Cymborowski, M]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Edwards, A]]
[[Category: Cymborowski M]]
[[Category: Evdokimova, E]]
[[Category: Edwards A]]
[[Category: Joachimiak, A]]
[[Category: Evdokimova E]]
[[Category: Structural genomic]]
[[Category: Joachimiak A]]
[[Category: Minor, W]]
[[Category: Minor W]]
[[Category: Osipiuk, J]]
[[Category: Osipiuk J]]
[[Category: Savchenko, A]]
[[Category: Savchenko A]]
[[Category: Hypothetical protein]]
[[Category: Mcsg]]
[[Category: Pa0094]]
[[Category: PSI, Protein structure initiative]]
[[Category: Unknown function]]

Latest revision as of 11:42, 14 February 2024

Crystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative RegulatorCrystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative Regulator

Structural highlights

1tu1 is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

EAGT6_PSEAE Plays an essential role in toxin Tse6 delivery to target cells and specifically in the loading of Tse6 onto VgrG1a.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Quentin D, Ahmad S, Shanthamoorthy P, Mougous JD, Whitney JC, Raunser S. Mechanism of loading and translocation of type VI secretion system effector Tse6. Nat Microbiol. 2018 Sep 3. pii: 10.1038/s41564-018-0238-z. doi:, 10.1038/s41564-018-0238-z. PMID:30177742 doi:http://dx.doi.org/10.1038/s41564-018-0238-z

1tu1, resolution 1.95Å

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