1ess: Difference between revisions

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-[[Image:1ess.gif|left|200px]]
- {{Structure
+==STEROID TETHERED DNA, NMR, MINIMIZED AVERAGE STRUCTURE==
-|PDB= 1ess |SIZE=350|CAPTION= <scene name='initialview01'>1ess</scene>
+<StructureSection load='1ess' size='340' side='right'caption='[[1ess]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ESO:O3-PHOSPHONOESTRONE'>ESO</scene>
+<table><tr><td colspan='2'>[[1ess]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ESS FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ESO:O3-PHOSPHONOESTRONE'>ESO</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ess FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ess OCA], [https://pdbe.org/1ess PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ess RCSB], [https://www.ebi.ac.uk/pdbsum/1ess PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ess ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ess FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ess OCA], [http://www.ebi.ac.uk/pdbsum/1ess PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ess RCSB]</span>
+<div style="background-color:#fffaf0;">
-}}
+== Publication Abstract from PubMed ==
-'''STEROID TETHERED DNA, NMR, MINIMIZED AVERAGE STRUCTURE'''
-==Overview==
 The solution structure of an estrone (Es)-tethered tandem DNA duplex consisting of two Es-tethered tetranucleotides and a target octameric DNA sequence is reported. The structure of this Es-tethered tandem duplex has been compared with a corresponding natural tandem duplex without estrones. The Tm of the 3'-Es-tethered tetranucleotide part of the tandem duplex increases by 5 degrees C, whereas the Tm of the 5'-Es-tethered tetranucleotide part increases by 7 degrees C, compared with the corresponding natural counterpart. The NMR structures of both the Es-tethered tandem duplex and the natural counterpart have been based on 24 experimental NMR constraints per residue. Despite the fact that there is considerable distortion at the junction of two Es-tethered tetranucleotides in the major groove of the Es-tethered DNA duplex compared to the natural counterpart, both duplexes do take up B-type DNA structures. It is likely that the spatial proximity of two Es residues, and the resulting hydrophobic interaction between them might be responsible for the increase of the thermal stability of the Es-tethered tandem duplex in comparison with the natural counterpart.
-==About this Structure==
+The NMR structure of estrone (Es)-tethered tandem DNA duplex: [d(5'pCAGCp3')-Es] + [Es-d(5'pTCCA3')]: d(5'pTGGAGCTG3').,Denisov AY, Sandstrom A, Maltseva TV, Pyshnyi DV, Ivanova EM, Zarytova VF, Chattopadhyaya J J Biomol Struct Dyn. 1997 Dec;15(3):499-516. PMID:9439997<ref>PMID:9439997</ref>
-ESS is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESS OCA].
-==Reference==
-The NMR structure of estrone (Es)-tethered tandem DNA duplex: [d(5'pCAGCp3')-Es] + [Es-d(5'pTCCA3')]: d(5'pTGGAGCTG3')., Denisov AY, Sandstrom A, Maltseva TV, Pyshnyi DV, Ivanova EM, Zarytova VF, Chattopadhyaya J, J Biomol Struct Dyn. 1997 Dec;15(3):499-516. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9439997 9439997]
-[[Category: Protein complex]]
-[[Category: Chattopadhyaya, J.]]
-[[Category: Denisov, A.]]
-[[Category: Ivanova, E.]]
-[[Category: Maltseva, T.]]
-[[Category: Pyshnyi, D.]]
-[[Category: Sandstrom, A.]]
-[[Category: Zarytova, V.]]
-[[Category: deoxyribonucleic acid]]
-[[Category: dna]]
-[[Category: estrone]]
-[[Category: nmr]]
-[[Category: steroid tethered]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:08:53 2008''
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1ess" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Chattopadhyaya J]]
+[[Category: Denisov A]]
+[[Category: Ivanova E]]
+[[Category: Maltseva T]]
+[[Category: Pyshnyi D]]
+[[Category: Sandstrom A]]
+[[Category: Zarytova V]]