1s5o: Difference between revisions
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==Structural and Mutational Characterization of L-carnitine Binding to Human carnitine Acetyltransferase== | ==Structural and Mutational Characterization of L-carnitine Binding to Human carnitine Acetyltransferase== | ||
<StructureSection load='1s5o' size='340' side='right' caption='[[1s5o]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='1s5o' size='340' side='right'caption='[[1s5o]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1s5o]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1s5o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S5O FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=152:CARNITINE'>152</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5o OCA], [https://pdbe.org/1s5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s5o RCSB], [https://www.ebi.ac.uk/pdbsum/1s5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s5o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CACP_HUMAN CACP_HUMAN] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s5/1s5o_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s5/1s5o_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 35: | Line 36: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Agbandje-Mckenna | [[Category: Agbandje-Mckenna M]] | ||
[[Category: Govindasamy | [[Category: Govindasamy L]] | ||
[[Category: Gu | [[Category: Gu Y]] | ||
[[Category: Jin | [[Category: Jin S]] | ||
[[Category: Kukar | [[Category: Kukar T]] | ||
[[Category: Lian | [[Category: Lian W]] | ||
[[Category: Mckenna | [[Category: Mckenna R]] | ||
[[Category: Pedersen | [[Category: Pedersen B]] | ||
[[Category: Wu | [[Category: Wu D]] | ||