1emr: Difference between revisions

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-[[Image:1emr.jpg|left|200px]]
- {{Structure
+==CRYSTAL STRUCTURE OF HUMAN LEUKEMIA INHIBITORY FACTOR (LIF)==
-|PDB= 1emr |SIZE=350|CAPTION= <scene name='initialview01'>1emr</scene>, resolution 3.5&Aring;
+<StructureSection load='1emr' size='340' side='right'caption='[[1emr]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1emr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMR FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1emr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emr OCA], [https://pdbe.org/1emr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1emr RCSB], [https://www.ebi.ac.uk/pdbsum/1emr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1emr ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1emr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emr OCA], [http://www.ebi.ac.uk/pdbsum/1emr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1emr RCSB]</span>
+[https://www.uniprot.org/uniprot/LIF_HUMAN LIF_HUMAN] LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-'''CRYSTAL STRUCTURE OF HUMAN LEUKEMIA INHIBITORY FACTOR (LIF)'''
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/1emr_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
-EMR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMR OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1emr ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Betzel, C.]]
+[[Category: Betzel C]]
-[[Category: Hawkins, N.]]
+[[Category: Hawkins N]]
-[[Category: Heath, J K.]]
+[[Category: Heath JK]]
-[[Category: Jones, E Y.]]
+[[Category: Jones EY]]
-[[Category: Robinson, R C.]]
+[[Category: Robinson RC]]
-[[Category: Samal, B.]]
+[[Category: Samal B]]
-[[Category: 4-helix bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:05:38 2008''