2p6x: Difference between revisions

<StructureSection load='2p6x' size='340' side='right'caption='[[2p6x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[2p6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P6X FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p6x OCA], [https://pdbe.org/2p6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p6x RCSB], [https://www.ebi.ac.uk/pdbsum/2p6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p6x ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[https://omim.org/entry/152700 152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref>  

[https://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN] Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<ref>PMID:16461343</ref> <ref>PMID:18056643</ref> <ref>PMID:19167335</ref> <ref>PMID:21719704</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p6/2p6x_consurf.spt"</scriptWhenChecked>

*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Alfano I]]

[[Category: Arrowsmith CH]]

[[Category: Barr A]]

[[Category: Bunkoczi G]]

[[Category: Burgess-Brown N]]

[[Category: Edwards A]]

[[Category: King O]]

[[Category: Knapp S]]

[[Category: Papagrigoriou E]]

[[Category: Pike ACW]]

[[Category: Salah E]]

[[Category: Shrestha L]]

[[Category: Sundstrom M]]

[[Category: Turnbull A]]

[[Category: Ugochukwu E]]

[[Category: Umeano C]]

[[Category: Uppenberg J]]

[[Category: Weigelt J]]

[[Category: Von Delft F]]