1dqv: Difference between revisions

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-[[Image:1dqv.gif|left|200px]]
- {{Structure
+==CRYSTAL STRUCTURE OF SYNAPTOTAGMIN III C2A/C2B==
-|PDB= 1dqv |SIZE=350|CAPTION= <scene name='initialview01'>1dqv</scene>, resolution 3.2&Aring;
+<StructureSection load='1dqv' size='340' side='right'caption='[[1dqv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+<table><tr><td colspan='2'>[[1dqv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQV FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dqv OCA], [https://pdbe.org/1dqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dqv RCSB], [https://www.ebi.ac.uk/pdbsum/1dqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dqv ProSAT]</span></td></tr>
-|RELATEDENTRY=[[1rsy|1rsy]]
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dqv OCA], [http://www.ebi.ac.uk/pdbsum/1dqv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dqv RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/SYT3_RAT SYT3_RAT] May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dqv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dqv ConSurf].
+<div style="clear:both"></div>
-'''CRYSTAL STRUCTURE OF SYNAPTOTAGMIN III C2A/C2B'''
+==See Also==
+*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-Synaptotagmins are synaptic vesicle-associated, phospholipid-binding proteins most commonly associated with Ca(+2)-dependent exocytotic and Ca(+2)- independent endocytotic events. Synaptotagmin III is a 63.2-kD member of the synaptotagmin homology group; one of its characteristic properties is the ability to bind divalent cations and accessory proteins promiscuously. In the cytosolic portion of this protein, a flexible seven-amino acid linker joins two homologous C2 domains. The C2A domain binds to phospholipid membranes and other accessory proteins in a divalent cation-dependent fashion. The C2B domain promotes binding to other C2B domains, as well as accessory proteins independent of divalent cations. The 3.2 A crystal structure of synaptotagmin III, residues 295-566, which includes the C2A and C2B domains, exhibits differences in the shape of the Ca(+2)-binding pocket, the electrostatic surface potential, and the stoichiometry of bound divalent cations for the two domains. These observations may explain the disparate binding properties of the two domains. The C2A and the C2B domains do not interact; synaptotagmin, therefore, covalently links two independent C2 domains, each with potentially different binding partners. A model of synaptotagmin's involvement in Ca(+2)-dependent regulation of membrane fusion through its interaction with the SNARE complex is presented.
+[[Category: Large Structures]]
-==About this Structure==
-DQV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQV OCA].
-==Reference==
-Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction., Sutton RB, Ernst JA, Brunger AT, J Cell Biol. 1999 Nov 1;147(3):589-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10545502 10545502]
 [[Category: Rattus rattus]]
-[[Category: Single protein]]
+[[Category: Brunger AT]]
-[[Category: Brunger, A T.]]
+[[Category: Ernst JA]]
-[[Category: Ernst, J A.]]
+[[Category: Sutton RB]]
-[[Category: Sutton, R B.]]
-[[Category: beta sandwich]]
-[[Category: c2 domain]]
-[[Category: calcium ion]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:47:00 2008''