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==STRUCTURE OF TRYPANOTHIONE REDUCTASE FROM LEISHMANIA INFANTUM==
 
<StructureSection load='2jk6' size='340' side='right' caption='[[2jk6]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
==Structure of Trypanothione Reductase from Leishmania infantum==
<StructureSection load='2jk6' size='340' side='right'caption='[[2jk6]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiin Leiin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JK6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JK6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w0h|2w0h]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase Trypanothione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk6 OCA], [https://pdbe.org/2jk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jk6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk6 OCA], [http://pdbe.org/2jk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jk6 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk6 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A4HSF7_LEIIN A4HSF7_LEIIN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jk6_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jk6_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Leiin]]
[[Category: Large Structures]]
[[Category: Trypanothione-disulfide reductase]]
[[Category: Leishmania infantum]]
[[Category: Baiocco, P]]
[[Category: Baiocco P]]
[[Category: Colotti, G]]
[[Category: Colotti G]]
[[Category: Franceschini, S]]
[[Category: Franceschini S]]
[[Category: Ilari, A]]
[[Category: Ilari A]]
[[Category: Antimonial]]
[[Category: Fad]]
[[Category: Flavoprotein]]
[[Category: Leishmania]]
[[Category: Oxidant detoxification]]
[[Category: Oxidoreductase]]
[[Category: Redox-active center]]
[[Category: Trypanosoma]]
[[Category: Trypanothione metabolism]]

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