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==Crystal Structure of the Uridine Phosphorylase from Salmonella Typhimurium at 1.77A Resolution== | ==Crystal Structure of the Uridine Phosphorylase from Salmonella Typhimurium at 1.77A Resolution== | ||
<StructureSection load='1y1t' size='340' side='right' caption='[[1y1t]], [[Resolution|resolution]] 1.77Å' scene=''> | <StructureSection load='1y1t' size='340' side='right'caption='[[1y1t]], [[Resolution|resolution]] 1.77Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1y1t]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1y1t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y1T FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1t OCA], [https://pdbe.org/1y1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y1t RCSB], [https://www.ebi.ac.uk/pdbsum/1y1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1t ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/UDP_SALTY UDP_SALTY] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1t_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1t_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 23: | Line 22: | ||
==See Also== | ==See Also== | ||
*[[Uridine phosphorylase|Uridine phosphorylase]] | *[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]] | ||
[[Category: Betzel | [[Category: Betzel C]] | ||
[[Category: Dontsova | [[Category: Dontsova MV]] | ||
[[Category: Ealick | [[Category: Ealick SE]] | ||
[[Category: Gabdoulkhakov | [[Category: Gabdoulkhakov AG]] | ||
[[Category: Kachalova | [[Category: Kachalova GS]] | ||
[[Category: Mikhailov | [[Category: Mikhailov AM]] | ||
Latest revision as of 09:51, 23 August 2023
Crystal Structure of the Uridine Phosphorylase from Salmonella Typhimurium at 1.77A ResolutionCrystal Structure of the Uridine Phosphorylase from Salmonella Typhimurium at 1.77A Resolution
Structural highlights
FunctionUDP_SALTY Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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