2iip: Difference between revisions
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==Human Nicotinamide N-methyltransferase== | ==Human Nicotinamide N-methyltransferase== | ||
<StructureSection load='2iip' size='340' side='right' caption='[[2iip]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='2iip' size='340' side='right'caption='[[2iip]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2iip]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2iip]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IIP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iip OCA], [https://pdbe.org/2iip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iip RCSB], [https://www.ebi.ac.uk/pdbsum/2iip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iip ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NNMT_HUMAN NNMT_HUMAN] Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/2iip_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/2iip_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 22: | Line 22: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Avvakumov | [[Category: Avvakumov GV]] | ||
[[Category: Bernstein | [[Category: Bernstein G]] | ||
[[Category: Bochkarev | [[Category: Bochkarev A]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Loppnau | [[Category: Loppnau P]] | ||
[[Category: Min | [[Category: Min J]] | ||
[[Category: Plotnikov | [[Category: Plotnikov AN]] | ||
[[Category: Sundstrom M]] | |||
[[Category: Sundstrom | [[Category: Tempel W]] | ||
[[Category: Tempel | [[Category: Wasney G]] | ||
[[Category: Wasney | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Wu H]] | ||
[[Category: Wu | [[Category: Zeng H]] | ||
[[Category: Zeng | |||
Latest revision as of 12:03, 21 February 2024
Human Nicotinamide N-methyltransferaseHuman Nicotinamide N-methyltransferase
Structural highlights
FunctionNNMT_HUMAN Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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