2he2: Difference between revisions
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==Crystal structure of the 3rd PDZ domain of human discs large homologue 2, DLG2== | ==Crystal structure of the 3rd PDZ domain of human discs large homologue 2, DLG2== | ||
<StructureSection load='2he2' size='340' side='right' caption='[[2he2]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2he2' size='340' side='right'caption='[[2he2]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2he2]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2he2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HE2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2he2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he2 OCA], [https://pdbe.org/2he2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2he2 RCSB], [https://www.ebi.ac.uk/pdbsum/2he2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2he2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DLG2_HUMAN DLG2_HUMAN] Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2he2_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2he2_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 27: | Line 28: | ||
</div> | </div> | ||
<div class="pdbe-citations 2he2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2he2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith C]] | ||
[[Category: | [[Category: Berridge G]] | ||
[[Category: | [[Category: Debreczeni J]] | ||
[[Category: Doyle | [[Category: Doyle DA]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Elkins | [[Category: Elkins JM]] | ||
[[Category: Gorrec | [[Category: Gorrec F]] | ||
[[Category: Papagrigoriou | [[Category: Papagrigoriou E]] | ||
[[Category: Phillips | [[Category: Phillips C]] | ||
[[Category: Savitsky P]] | |||
[[Category: Savitsky | [[Category: Smee CEA]] | ||
[[Category: Smee | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Turnbull AP]] | ||
[[Category: Turnbull | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Von Delft F]] | ||
[[Category: | |||