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==Crystal structure of secreted chorismate mutase from Yersinia pestis==
==Crystal structure of secreted chorismate mutase from Yersinia pestis==
<StructureSection load='2gbb' size='340' side='right' caption='[[2gbb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2gbb' size='340' side='right'caption='[[2gbb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2gbb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis_biovar_mediaevails_str._91001 Yersinia pestis biovar mediaevails str. 91001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GBB FirstGlance]. <br>
<table><tr><td colspan='2'>[[2gbb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_biovar_Microtus_str._91001 Yersinia pestis biovar Microtus str. 91001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GBB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">y2828 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=229193 Yersinia pestis biovar Mediaevails str. 91001])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gbb OCA], [https://pdbe.org/2gbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gbb RCSB], [https://www.ebi.ac.uk/pdbsum/2gbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gbb ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gbb OCA], [http://pdbe.org/2gbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gbb RCSB], [http://www.ebi.ac.uk/pdbsum/2gbb PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCMU_YERPE SCMU_YERPE] Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity.<ref>PMID:18727669</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/2gbb_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/2gbb_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chorismate mutase]]
[[Category: Large Structures]]
[[Category: Yersinia pestis biovar mediaevails str. 91001]]
[[Category: Yersinia pestis biovar Microtus str. 91001]]
[[Category: Kim, S K]]
[[Category: Kim S-K]]
[[Category: Ladner, J E]]
[[Category: Ladner JE]]
[[Category: Nelson, B C]]
[[Category: Nelson BC]]
[[Category: Reddy, P T]]
[[Category: Reddy PT]]
[[Category: Robinson, H]]
[[Category: Robinson H]]
[[Category: Alpha helical bundle]]
[[Category: Isomerase]]

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