2eor: Difference between revisions

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==Solution structure of the C2H2 type zinc finger (region 255-287) of human Zinc finger protein 224==
==Solution structure of the C2H2 type zinc finger (region 255-287) of human Zinc finger protein 224==
<StructureSection load='2eor' size='340' side='right' caption='[[2eor]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2eor' size='340' side='right'caption='[[2eor]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2eor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2eor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eor OCA], [http://pdbe.org/2eor PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eor RCSB], [http://www.ebi.ac.uk/pdbsum/2eor PDBsum], [http://www.topsan.org/Proteins/RSGI/2eor TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eor OCA], [https://pdbe.org/2eor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eor RCSB], [https://www.ebi.ac.uk/pdbsum/2eor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eor ProSAT], [https://www.topsan.org/Proteins/RSGI/2eor TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN]] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref>
[https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eor_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eor_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 23: Line 24:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Abe, H]]
[[Category: Large Structures]]
[[Category: Kigawa, T]]
[[Category: Abe H]]
[[Category: Kobayashi, N]]
[[Category: Kigawa T]]
[[Category: Koshiba, S]]
[[Category: Kobayashi N]]
[[Category: Li, H]]
[[Category: Koshiba S]]
[[Category: Structural genomic]]
[[Category: Li H]]
[[Category: Saito, K]]
[[Category: Saito K]]
[[Category: Sato, M]]
[[Category: Sato M]]
[[Category: Tochio, N]]
[[Category: Tochio N]]
[[Category: Tomizawa, T]]
[[Category: Tomizawa T]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Transcription]]
[[Category: Zf-c2h2]]

Latest revision as of 21:53, 29 May 2024

Solution structure of the C2H2 type zinc finger (region 255-287) of human Zinc finger protein 224Solution structure of the C2H2 type zinc finger (region 255-287) of human Zinc finger protein 224

Structural highlights

2eor is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

ZN224_HUMAN May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Harada Y, Kanehira M, Fujisawa Y, Takata R, Shuin T, Miki T, Fujioka T, Nakamura Y, Katagiri T. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. Cancer Res. 2010 Jul 15;70(14):5829-39. doi: 10.1158/0008-5472.CAN-10-0255. Epub , 2010 Jun 29. PMID:20587513 doi:http://dx.doi.org/10.1158/0008-5472.CAN-10-0255
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