5hq2: Difference between revisions
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==Structural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core particle== | |||
<StructureSection load='5hq2' size='340' side='right'caption='[[5hq2]], [[Resolution|resolution]] 4.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hq2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HQ2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.5Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hq2 OCA], [https://pdbe.org/5hq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hq2 RCSB], [https://www.ebi.ac.uk/pdbsum/5hq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hq2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
==See Also== | |||
*[[Histone 3D structures|Histone 3D structures]] | |||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Tan | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: McGinty RK]] | |||
[[Category: Tan S]] | |||
[[Category: Tavarekere G]] | |||
Latest revision as of 15:32, 6 March 2024
Structural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core particleStructural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core particle
Structural highlights
FunctionH32_XENLA Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. See Also |
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