5dkr: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==Crystal Structure of Calcium-loaded S100B bound to SBi29==
-<StructureSection load='5dkr' size='340' side='right' caption='[[5dkr]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
+<StructureSection load='5dkr' size='340' side='right'caption='[[5dkr]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5dkr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DKR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5dkr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DKR FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CZ:2-[4-(4-CARBAMIMIDOYLPHENOXY)PHENYL]-1H-INDOLE-6-CARBOXIMIDAMIDE'>5CZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.742&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dkn|5dkn]], [[5dkq|5dkq]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CZ:2-[4-(4-CARBAMIMIDOYLPHENOXY)PHENYL]-1H-INDOLE-6-CARBOXIMIDAMIDE'>5CZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dkr OCA], [http://pdbe.org/5dkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dkr RCSB], [http://www.ebi.ac.uk/pdbsum/5dkr PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dkr OCA], [https://pdbe.org/5dkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dkr RCSB], [https://www.ebi.ac.uk/pdbsum/5dkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dkr ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
+[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 19: @@
 </div>
 <div class="pdbe-citations 5dkr" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[S100 proteins 3D structures|S100 proteins 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Alasady, M J]]
+[[Category: Bos taurus]]
-[[Category: Ansari, M I]]
+[[Category: Large Structures]]
-[[Category: Bezawada, P]]
+[[Category: Alasady MJ]]
-[[Category: Cavalier, M C]]
+[[Category: Ansari MI]]
-[[Category: Coop, A]]
+[[Category: Bezawada P]]
-[[Category: MacKerell, A D]]
+[[Category: Cavalier MC]]
-[[Category: McKnight, L E]]
+[[Category: Coop A]]
-[[Category: Neau, D B]]
+[[Category: MacKerell Jr AD]]
-[[Category: Pierce, A D]]
+[[Category: McKnight LE]]
-[[Category: Raman, E P]]
+[[Category: Neau DB]]
-[[Category: Toth, E A]]
+[[Category: Pierce AD]]
-[[Category: Varney, K M]]
+[[Category: Raman EP]]
-[[Category: Weber, D J]]
+[[Category: Toth EA]]
-[[Category: Wilder, P T]]
+[[Category: Varney KM]]
-[[Category: Calcium binding]]
+[[Category: Weber DJ]]
-[[Category: Complex]]
+[[Category: Wilder PT]]
-[[Category: Covalent inhibitor]]
-[[Category: Malignant melanoma]]
-[[Category: Metal binding protein-inhibitor complex]]