Connexin: Difference between revisions
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Of notice, about half of all cases of human pre-lingual recessive deafness in countries surrounding the Mediterranean have been linked to mutations in the GJB2 gene<ref name='important'>pmid 24624091</ref>,<ref name='Structure'>pmid 19622859</ref> | Of notice, about half of all cases of human pre-lingual recessive deafness in countries surrounding the Mediterranean have been linked to mutations in the GJB2 gene<ref name='important'>pmid 24624091</ref>,<ref name='Structure'>pmid 19622859</ref> | ||
*'''Connexin 26''' participates in K+ transport in sensory hair cells in the ear and its mutations are causes of deafness<ref>pmid 9285800</ref> | |||
*'''Connexin 31''' mutations are associated with skin and auditory system disorders<ref>PMID 16549784</ref> | |||
*'''Connexin 32''' is found in the peripheral nervous system and its mutations are associated with Charcot-Marie-Tooth disease<ref>PMID 30042657</ref> | |||
*'''Connexin 36''' regulates the in vivo dynamics of insulin secretion which is important for glucose homeostasis<ref>PMID 22511206</ref> | |||
*'''Connexin 40''' is found in the atrial myocardium and its mutations are associated with trial fibrillation<ref>PMID 19535379</ref> | |||
*'''Connexin 43''' renders glioblastoma resistant to chemotherapy<ref>PMID 35022385</ref> | |||
*'''Connexin 45''' is involved in the maturation of vessel<ref>PMID 10976050</ref> | |||
*'''Connexin 46''' is found in the eye lens and is unregulated in human breast cancer<ref>PMID 32353936</ref> | |||
*'''Connexin 50''' functions as adhesive molecule maintaining lens fibre integrity<ref>PMID 28706245</ref> | |||
[[image:co.jpg | thumb |650px | center | The overall connexon's structure]] <ref>http://en.wikipedia.org/wiki/Connexin</ref> | [[image:co.jpg | thumb |650px | center | The overall connexon's structure]] <ref>http://en.wikipedia.org/wiki/Connexin</ref> | ||
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=3D structures of connexin= | =3D structures of connexin= | ||
[[Connexin 3D structure]] | |||
</StructureSection> | |||
= References = | = References = | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||