5fi6: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 5fi6 is ON HOLD
+==Crystal structure of human GAC in complex with inhibitor UPGL_00011: 2-phenyl-~{N}-[5-[[(3~{S})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide==
+<StructureSection load='5fi6' size='340' side='right'caption='[[5fi6]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fi6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FI6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5XY:2-PHENYL-~{N}-[5-[[(3~{S})-1-[5-(2-PHENYLETHANOYLAMINO)-1,3,4-THIADIAZOL-2-YL]PYRROLIDIN-3-YL]AMINO]-1,3,4-THIADIAZOL-2-YL]ETHANAMIDE'>5XY</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi6 OCA], [https://pdbe.org/5fi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fi6 RCSB], [https://www.ebi.ac.uk/pdbsum/5fi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
-Authors: Qingqiu Huang, Richard Cerione
+==See Also==
+*[[Glutaminase 3D structures|Glutaminase 3D structures]]
-Description: Crystal structure of human GAC in complex with inhibitor UPGL_00011
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Qingqiu Huang, Richard Cerione]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Cerione R]]
+[[Category: Huang Q]]