5fg4: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fg4 is ON HOLD
+==Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe==
+<StructureSection load='5fg4' size='340' side='right'caption='[[5fg4]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FG4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5XE:4-BROMANYL-~{N}-(6-METHOXY-1,3-DIMETHYL-2-OXIDANYLIDENE-BENZIMIDAZOL-5-YL)-2-METHYL-BENZENESULFONAMIDE'>5XE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg4 OCA], [https://pdbe.org/5fg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fg4 RCSB], [https://www.ebi.ac.uk/pdbsum/5fg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fg4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
-Authors: Tallant, C., Owen, D.R., Gerstenberger, B.S., Savitsky, P., Chaikuad, A., Fedorov, O., Nunez-Alonso, G., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
+==See Also==
+*[[Peregrin|Peregrin]]
-Description: Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Gerstenberger, B.S]]
+__TOC__
-[[Category: Chaikuad, A]]
+</StructureSection>
-[[Category: Owen, D.R]]
+[[Category: Homo sapiens]]
-[[Category: Nunez-Alonso, G]]
+[[Category: Large Structures]]
-[[Category: Fedorov, O]]
+[[Category: Arrowsmith CH]]
-[[Category: Muller, S]]
+[[Category: Bountra C]]
-[[Category: Knapp, S]]
+[[Category: Chaikuad A]]
-[[Category: Bountra, C]]
+[[Category: Edwards AM]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Fedorov O]]
-[[Category: Von Delft, F]]
+[[Category: Filippakopoulos P]]
-[[Category: Filippakopoulos, P]]
+[[Category: Gerstenberger BS]]
-[[Category: Edwards, A.M]]
+[[Category: Knapp S]]
-[[Category: Tallant, C]]
+[[Category: Muller S]]
-[[Category: Savitsky, P]]
+[[Category: Nunez-Alonso G]]
+[[Category: Owen DR]]
+[[Category: Savitsky P]]
+[[Category: Tallant C]]
+[[Category: Von Delft F]]