Interferon receptor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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-<StructureSection load='3s9d' size='350' side='right' caption='Structure of interferon α/β receptor β chain ectodomain (green and yellow) complex with interferon-α 2 (grey and pink) and Cl- ion (green) (PDB entry [[3s9d]])' scene=''>
+<StructureSection load='3s9d' size='350' side='right' caption='Structure of interferon α/β receptor β chain ectodomain (yellow) complex with interferon-α 2 (pink) and Cl- ion (green) (PDB entry [[3s9d]])' scene=''>
+== Function ==
 '''Interferon receptor''' (IFNR) is a cell surface receptor which binds interferon.<br />
-*  '''Interferon α/β receptor''' binds interferon-α and interferon-β.  It is a heterodimer with subunits INFAR1 and INFAR2.  For more details see [[IFNAR]]<br />
+*  '''Interferon α/β receptor''' binds interferon-α and interferon-β.  It is a heterodimer with subunits INFAR1 and INFAR2<ref>PMID:17969444</ref>.  For more details see [[IFNAR]] and [[Multiple sclerosis]].<br />
-*  '''Interferon γ receptor''' binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2.<br />
+*  '''Interferon γ receptor''' binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2<ref>PMID:9462485</ref>.<br />
-*  '''Interferon δ receptor''' binds interferon-δ.
+*  '''Interferon δ receptor''' binds interferon-δ<ref>PMID:9865499</ref>.
-</StructureSection>
-==3D structures of interferon receptor==
+See also: [[Cytokine receptors]].
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+== Relevance ==
-{{#tree:id=OrganizedByTopic|openlevels=0|
+Lack of neuronal interferon α/β receptor causes Lewy Body and Parkinson-like dementia in mice<ref>PMID:16451483</ref>.  Interferon α/β receptor deficiency has a role in the pathogenesis of lupus<ref>PMID:12642605</ref>.
-*Interferon α/β receptor
+== Disease ==
+Mutations of interferon γ receptor confer susceptibility to infections caused by mycobacteria<ref>PMID:10192386</ref>.
-**[[3s98]] – hINFAR1 ectodomain – human <br />
+==3D structures of interferon receptor==
-**[[1n6u]], [[1n6v]] – hINFAR2 ectodomain - NMR <br />
+[[Interferon receptor 3D structures]]
-**[[3s8w]] – hINFAR2 D2 domain - NMR <br />
-**[[2hym]], [[2kz1]], [[2lag]] – hINFAR2 ectodomain + interferon-α 2 - NMR <br />
-**[[3s9d]] – hINFAR2 ectodomain + interferon-α 2  <br />
-**[[3se3]] – hINFAR2 ectodomain + hINFAR1 ectodomain + interferon-α 2  <br />
-**[[3se4]] – hINFAR2 ectodomain + hINFAR1 ectodomain + interferon-ω 1  <br />
-**[[3wcy]] – INFAR1 ectodomain + interferon-β - mouse <br />
-*Interferon γ receptor
+</StructureSection>
-**[[1jrh]] – hINFGR1 N terminal (mutant) + antibody  <br />
-**[[1fg9]], [[1fyh]] – hINFGR1 extracellular domain + interferon-γ  <br />
-**[[4eq2]], [[4eq3]] – INFGR1 α chain - chicken  <br />
-*Interferon δ receptor
-**[[3og4]], [[3og6]] – hINFDR1 extracellular domain + interleukin-29  <br />
+== References ==
-}}
+<references/>
 [[Category:Topic Page]]