5f8x: Difference between revisions

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-'''Unreleased structure'''
-The entry 5f8x is ON HOLD
+==The crystal structure of human plasma kallikrein in complex with its peptide inhibitor pkalin-3==
+<StructureSection load='5f8x' size='340' side='right'caption='[[5f8x]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5f8x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj6 4zj6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F8X FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8x OCA], [https://pdbe.org/5f8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f8x RCSB], [https://www.ebi.ac.uk/pdbsum/5f8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8x ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
+== Function ==
+[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
-Authors: Xu, M., Jiang, L., Xu, P., Luo, Z., Andreasen, P., Huang, M.
+==See Also==
+*[[Kallikrein 3D structures|Kallikrein 3D structures]]
-Description: THE CRYSTAL STRUCTURE OF HUMAN PLASMA KALLIKREIN IN COMPLEX WITH ITS PEPTIDE INHIBITOR PKALIN-3
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Andreasen, P]]
+[[Category: Homo sapiens]]
-[[Category: Xu, P]]
+[[Category: Large Structures]]
-[[Category: Xu, M]]
+[[Category: Synthetic construct]]
-[[Category: Huang, M]]
+[[Category: Andreasen P]]
-[[Category: Jiang, L]]
+[[Category: Huang M]]
-[[Category: Luo, Z]]
+[[Category: Jiang L]]
+[[Category: Luo Z]]
+[[Category: Xu M]]
+[[Category: Xu P]]