|
|
| (8 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
|
| | <StructureSection load='3p1c' size='350' side='right' scene='54/541099/Cv/1' caption='Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]]'> |
| [[Image:1kbh.png|left|200px|thumb|Crystal structure of CREB-binding protein bromodomain (green) complex with nuclear receptor coactivator (grey) [[1kbh]]]]
| |
| {{STRUCTURE_3p1c| PDB=3p1c | SIZE=350| SCENE= |right|CAPTION=Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]] }}
| |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| == Function == | | == Function == |
|
| |
|
| '''CREB-binding protein''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref> | | '''CREB-binding protein''' or '''CREBBP''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref> |
|
| |
|
| == Disease == | | == Disease == |
| Line 35: |
Line 12: |
| CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73. | | CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73. |
|
| |
|
| == 3D Structures of CREB-binding protein == | | <scene name='54/541099/Cv/5'>Acetyllysine binding site</scene> with chain A. Water molecules are shown as red spheres. |
|
| |
|
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | <scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| |
|
| |
|
| *CBP
| | == 3D Structures of CREB-binding protein == |
| | | [[CREB-binding protein 3D structures]] |
| **[[4i9o]] – mCBP GACKIX domain (mutant) - mouse <br />
| |
| **[[1f81]] – mCBP TAZ2 domain - NMR <br />
| |
| **[[1u2n]] – mCBP TAZ1 domain - NMR <br />
| |
| **[[1jjs]] – mCBP IBiD domain - NMR<br />
| |
| **[[1liq]] – mCBP CH1 domain - NMR<br />
| |
| **[[1tot]] – mCBP ZZ domain – NMR <br />
| |
| **[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />
| |
| **[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
| |
| **[[2d82]] – hCBP bromodomain - NMR<br />
| |
| **[[3dwy]] – hCBP bromodomain <br />
| |
| **[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]] – hCBP bromodomain + small molecule<br />
| |
| **[[2l84]], [[2l85]] – hCBP bromodomain + small molecule - NMR<br />
| |
|
| |
|
| *CBP complex with protein
| | </StructureSection> |
|
| |
|
| **[[1kbh]] – hCBP + nuclear receptor coactivator - NMR <br />
| |
| **[[1zoq]] – hCBP + interferon regulatory factor 3 <br />
| |
| **[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR<br />
| |
| **[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - NMR <br />
| |
| **[[1l8c]] – mCBP TAZ1 domain + hypoxia-inducible factor 1α - NMR<br />
| |
| **[[2lww]] - mCBP TAZ1 domain + nuclear transcription factor RELA – NMR <br />
| |
| **[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />
| |
| **[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />
| |
| **[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />
| |
| **[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />
| |
| **[[1jsp]] – hCBP bromodomain + p53 peptide - NMR<br />
| |
| **[[2l14]] – mCBP nuclear coactivator binding domain + p53 peptide - NMR<br />
| |
| **[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />
| |
| **[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />
| |
| **[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />
| |
| **[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />
| |
| **[[2lxs]], [[2lxt]] – hCBP KIX domain + histone methyltransferase MLL peptide – NMR <br />
| |
| **[[2rny]] – hCBP bromodomain + histone H3 peptide - NMR<br />
| |
| **[[4n3w]], [[4n4f]] - hCBP bromodomain + histone H4 peptide <br />
| |
| **[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />
| |
| }}
| |
| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |