5ex7: Difference between revisions

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==Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA==
==Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA==
<StructureSection load='5ex7' size='340' side='right' caption='[[5ex7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5ex7' size='340' side='right'caption='[[5ex7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ex7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EX7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ex7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila Drosophila] and [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EX7 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ex7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ex7 OCA], [http://pdbe.org/5ex7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ex7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ex7 PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ex7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ex7 OCA], [https://pdbe.org/5ex7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ex7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ex7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ex7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BRAT_DROME BRAT_DROME]] Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.<ref>PMID:11274060</ref> <ref>PMID:11807032</ref>
[https://www.uniprot.org/uniprot/BRAT_DROME BRAT_DROME] Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.<ref>PMID:11274060</ref> <ref>PMID:11807032</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Liu, C P]]
[[Category: Drosophila]]
[[Category: Wang, M]]
[[Category: Drosophila melanogaster]]
[[Category: Wang, Y]]
[[Category: Large Structures]]
[[Category: Xu, R M]]
[[Category: Liu CP]]
[[Category: Yang, N]]
[[Category: Wang M]]
[[Category: Yu, Z]]
[[Category: Wang Y]]
[[Category: Brat-nhl]]
[[Category: Xu RM]]
[[Category: Hunchback mrna]]
[[Category: Yang N]]
[[Category: Translation-rna complex]]
[[Category: Yu Z]]

Latest revision as of 11:31, 12 July 2023

Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNACrystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA

Structural highlights

5ex7 is a 2 chain structure with sequence from Drosophila and Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BRAT_DROME Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.[1] [2]

References

  1. ↑ Sonoda J, Wharton RP. Drosophila Brain Tumor is a translational repressor. Genes Dev. 2001 Mar 15;15(6):762-73. PMID:11274060 doi:http://dx.doi.org/10.1101/gad.870801
  2. ↑ Frank DJ, Edgar BA, Roth MB. The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis. Development. 2002 Jan;129(2):399-407. PMID:11807032

5ex7, resolution 2.60Å

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